Basic Information
Symbol
CD81
RNA class
mRNA
Alias
CD81 Molecule
TSPAN28
Tetraspanin-28
TAPA1
S5.7
CD81 Antigen (Target Of Antiproliferative Antibody 1)
26 KDa Cell Surface Protein TAPA-1
CD81 Antigen
Tspan-28
TAPA-1
Target Of The Antiproliferative Antibody 1
CVID6
Location (GRCh38)
11:2376166-2397802
Forensic tag(s)
-
MANE select
Transcript ID
NM_004356.4
Sequence length
1482.0 nt
GC content
0.6235
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-595.70 kcal/mol
Thermodynamic ensemble
Free energy:
-621.62 kcal/mol
Frequency:
0.0000
Diversity:
557.09
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((.((((((.(((((.(((..(((((((..(((((.(.((.....((((.....(((.(((....(((((...((((.....))))....)))))...((((....))))..........(((....))).....((((.((.(((...))).)).))))....))).)))...)))).))))))))))))))).((((((((((.(((...))).))))((((.((((((...........)).)))).))))(((((...))))).......((((((((((((((((((....(((((((((((.((.(((((.(((.((.((((((((((...........))))).)))))..)).)))...))))).))......)))))))))))..(((((.((((.((((.....((((((....)))))).....(((((..((((((((.((.((.((((.((((((....(((((((...((((((.(((((((..((((((....))))))((.(.((((((((.((((((((((.(((((((((........)))..(((((((((((..(((((....))))).)))))).)))..)).....))))))....))))))))))...(((((.(((..(((((........))))).....)))...))))))))))))).).))((((((...((((((((..((((.((.((((.......))))..))))))..)))...))))).....))))))...((((((((((((......(((...(((((....))))).)))((...((((((.........))))))...))..((((........)))).))))))))(((((((((.....)))))))))...))))....))))).((((((.(((((.(((.(....)))).))))).))))))...))))))))))))))).))))).).)))).))))))))))))....)))))..((((....))))(((.((......)).))))))).......(((((((.(..(((..((((((((((((((((..........(((....((((.......))))...)))...........)))))).)))).........)))))).)))..).))))))))))).))))).)))))))).))))))))))))))))...(((((((....)))))))....))).)))))..(((((.....)))))(((...)))(((((.((((((.(((((((((((..((.((((((((......((((((((.......)))))))))))))))).))..)))............))))...)))).)))))).))))).))))))))).....((((.(((........))).)).))..................((((((((.(((.((..........)).)))...))))).)))...
Thermodynamic Ensemble Prediction
(({{(((({({(.(((((....(({((((.,(({((((......{{((((....,(({.(({....(((((...||||.....||||....))))}...||||....)))),.........|||}.,,|||{,,..((((,((.{((,,,|||.|},|||}....}}}.)))...|||||||{..|,,}}}||}}.,((,,(((((.(((...))).)))))||||||}}||||}|||||.,|||{{|{{(((((((({{...}}|||...{{{{{{{{{{{.{{{{{{{,......{{({{{{||,{|||,||{||||{|.{{{((({,{{((({(((((({{(.{{...}}.},)),),,..(({..((((.......)))).))),.}...,||||||||{{|,{,......((((((....)))))}.......|.|}}||||||{({{{{({.{,||}|||||,....|||||||}}}||||||}}}}}}}}.,{(((((....}))))|{{.{.((((((((.((((((((((.(((((({(({,,,{.|.|||{.{{(({{{||||,,||{{{,,..))))).)||}||,}}}..,),}.,,))))))....))))))))))...(((((.(((.{(((((........))))}.}...)))...))))))))))))).}.}}|{{{{,.,{({{{{{(({{((((,{{.((({.......})}}..}}}}}}..))))}.})}}}......||||||{{{{,|||||||||......,}||..(((((....))))).,,))}}}}||||||,.{{,{{,.,|||||...))}}|,,|....,,,,)|||,.,,,))))(((((((((,...,)))))))))...,)))}})),,,,)}|||,||}|||||,|(({({,,.||||,|}}||.}}||||,{..{|||,,,|||||||{|}},,})})),,.,))))}|,{(((({{{||||,..,{{,,,,,),}})))))))}....,.}))),,)}}}}}..,|||||})},..,,,..|||||||,|}||||||.,,}}}}..|||||,..||,,..,,,|,}}}}...}}|{,,,,.....,}))}|,|||||,,,..,.{|||||}|||||,{||||||||||||||||||||{|}|||.|.}}(((((((({....})))))))),((.((((((((.{....(((((,.....)))))..,}))))))).))....(((((.((((((.((({|{{,(((..(({((((((((......((((((((.......)))))))))))))))).}}..}},.......,||||}}}|,|.}))).)))))).))))).})))))))}..|||||||,||{|||,,,..,,},}},}},,.....|||........{{{{{(((.{{{,||.,,.....,,)),)))...})))),)))...
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| GGUUCCUUGUGGCCACAUUUCCAGUACCCAGUAGUCAUCUGUGCCAGGG… | 1354 nt | 0.5746 | |
| GGCCAGAGAGCGAGCGCGCAACGGCGGCGACGGCGGCGACCCCACCGCG… | 1478 nt | 0.6238 | |
| GGCCAGAGAGCGAGCGCGCAACGGCGGCGACGGCGGCGACCCCACCGCG… | 1479 nt | 0.6234 | |
| GGCCAGAGAGCGAGCGCGCAACGGCGGCGACGGCGGCGACCCCACCGCG… | 1482 nt | 0.6235 |
Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Forensic Context
No relevant information is available at the moment.