Basic Information

Symbol
CDK1
RNA class
mRNA
Alias
Cyclin Dependent Kinase 1 CDC28A CDC2 Cell Division Cycle 2, G1 To S And G2 To M Cell Division Control Protein 2 Homolog Cell Division Protein Kinase 1 Cyclin-Dependent Kinase 1 P34 Protein Kinase P34CDC2 Cell Cycle Controller CDC2 EC 2.7.11.22 EC 2.7.11.23 CDKN1
Location (GRCh38)
10:60778312-60796236
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001786.5
Sequence length
1889.0 nt
GC content
0.3536

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-466.00 kcal/mol
Thermodynamic ensemble
Free energy: -506.53 kcal/mol
Frequency: 0.0000
Diversity: 596.49
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...((((((.((((.....((((((.(........).))))))..((((((.((((((((....)))))))).))))))............(((((((((((((.((((.........))))...................((((...(((((((((((...(((((((..........((((........))))(((.....(((((....(((......)))((((...((((((((((((.(((((((((((((.........((((....))))))))..))))))))).))(((((.....(((...(((((((..(.(((....))).)..((((((......((((....)))).......)).)))).)))))))...))))))))........(((..((....))..)))))))))))))......)))).....)))))...))).(((((((((..((((((...((((.((((....))))..))))...)))))).....)))))))))..((((((((((((((........(((((.............))))).(((((((((((...(((((((((...(((((.....)).)))..)))))))))...)).))))))))).(((((((..(((((..((..((..(((((((.......)))))))..))..)).......))))).)))))))........((((...(((.((((((....((......))...))))))))).(((((.....(((((....)))))...))))).)))).((((((((((..........(((.(((((((((((.....((.((((((((((((((((...((((((((.((((((((..(((((((...(((((.(((((.......................)))))))))).......(((.(((......)).).))))))))))..))))..)))).)))................))))).)))))))).......)))))))).))...((((....))))..))))))))))).)))........))))))))))...........)))))))))))))))))))))...))))))..)))))...))))...(((((.((........))..))))).((((.(((((.......)))))))))..)))).)))))))))...(((((((....)))))))..................)))).))))))....((((......(((((.(((......))).)))))))))...((((((((....((((((.((((((....(((..(((((((.......)))))))..))).(((........)))(((.(((((((..((((((((((((((((((....((((..((((((((.(((((.......))))).))))..)))).(((((((........)))))))......))))....))))))))))))))))))))))))).)))...(((((((((((...............((((((((..(((.(....(((((((((..((((....)))).(((((((((((.((((((..........)))))).(((......)))((((..(((((...........))))).)))).......)))))))))))..)))))))))....).)))))))))))(((..(((..(((((((..(....)..))))))))))..))))))))))))))((((...))))....((((((....(((((.((((((.((((.........)))))))))).)))))....))))))..)))))).))))))..))))))))..........
Thermodynamic Ensemble Prediction
{{.....}}{(((((((((((((((.(........).))))))..((((((.((((((((....)))))))).))))))............,{({(((,(((((.,,,,.......,|}))).,},}}...{{,,...........|}||,,,.|||{{||.(({{|((({{{.{,..,,}},)}})},..||}.,,{{{{{(((((((...{,,......(((((((.((((((.((((,{({(,(({((({.((({{(,...,,((((...,||||,.....})))},,,,..,(((({.....{({...(((((((|.{.(((....))).|..((((((......((((....)))).......)).)))),)))))))...)))))))}....,,},|}}}}},}}}}})..|||{|||||,,,,....{((({.,,..,,{{,.{{((({....}))))||,||,,,|,.}||||.||||}}},)}||{,}|||{,.,|||,}.,{{{||||||||||{((((((((((((({......,,,{(({{{{,{{,{{{|,,|||||{((((((((({,...(((((((((...((({(.....)).})}..)))))))))...}}.))))))))).,{(((({..{||||,.((,.{(..(((((((.......})))))).,||,,,,.....,,||||}.}))))))..,,{,..{{,{,{{{((,({((((,{{,{,...|||.....|||}}}}}|,|||||..,,|{((({{{{.|,}},...,),,},))}|}||||||||||.,}},...,,(({.{((((((((({..,..|{.{(((((((((((((({,,,{(((((((.{({{{(({..(((((({...(((({{(((((.......................)))))))))).......,||,||(,....,)).}.))))))))))..})))..))}}.}}}.....,.,.....,,.))))),)))))))).......)))))))}.}}...{{{{.,,.}}}}..))))))))))).))}.....,,})))}}}})))}},........})))))))))))))).,||||{,{||,||{,.||,.,...,,,......,,,.{{........}}..,,,|{{{.((((((((((..,.,,.((((.{((((.(((((((.(((({..(((((({....}))))))...,,,,,,,,|.......,{,{{{{{,,,.,.{(((......(((((.((,......})).))))})))}..}}}}}}},,||||((((((,{{({{{.,,,,}},,..,,|))}}}}|}|||,,.|((((((........))}}}))}||||,,,,}},,((((((((((((((((((....{({,..{,{,((((.(((((.......))))).))))..||}},(((((((........))))))}...,,.,)))....)))))))))))))))))).)))))...))))))).))))})))}.,.,,..))))))))))|||((((((({{..{{{...|||,|.,}.}}}}}}),.{,,....,,|||,.,{{{{{....,|||,,|||}||,,{{......}})}}|.}}||||||}||,,,,,,.,,.,,,,|,.....,})))})))))))}),})})))},}}}}.,}))}}.,}},,.,||,,}}||,||||,,,..|}},})}})))}))}.)))),)))))).))))))).}}}....)))).}}}}}})}}..{((((.((((((.((((.........)))))))))).))))}.............)))))))))}........,||,..........

Transcripts

ID Sequence Length GC content
NM_001170406.1 NCBI
AGCCGCCCUUUCCUCUUUCUUUCGCGCUCUAGCCACCCGGGAAGGCCUG… 1754 nt 0.3392
NM_001320918.1 NCBI
AGCCGCCCUUUCCUCUUUCUUUCGCGCUCUAGCCACCCGGGAAGGCCUG… 1935 nt 0.3571
NM_001786.5 NCBI
GCACUUGGCUUCAAAGCUGGCUCUUGGAAAUUGAGCGGAGAGCGACGCG… 1889 nt 0.3536
NM_033379.5 NCBI
GCACUUGGCUUCAAAGCUGGCUCUUGGAAAUUGAGCGGAGAGCGACGCG… 1718 nt 0.3522
Summary

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2023]

Forensic Context

A study in humans demonstrated that the mRNA of the CDK1 was significantly upregulated in salivary extracellular vesicles from both emergency department patients with acute head trauma (p=0.055) and outpatient concussion clinic patients (p=0.006) when compared to healthy controls, with no significant difference between the two patient groups [Cheng et al. DOI:10.1002/jcp.28139]. A study in mice demonstrated that the CDK1 was identified as a top 10 differentially expressed gene and its expression was upregulated in burn tissue based on weighted gene coexpression network analysis [Guo et al. DOI:10.1155/2022/5220403].