Basic Information

Symbol
CDKN3
RNA class
mRNA
Alias
Cyclin Dependent Kinase Inhibitor 3 CDI1 KAP CDK2-Associated Dual Specificity Phosphatase Cyclin-Dependent Kinase Interactor 1 Cyclin-Dependent Kinase Inhibitor 3 Cyclin-Dependent Kinase Inhibitor Kinase-Associated Phosphatase CIP2 Cyclin-Dependent Kinase Interacting Protein 2 Cyclin-Dependent Kinase-Interacting Protein 2 CDK2-Associated Dual-Specificity Phosphatase Cdk-Associated Protein Phosphatase Kinase Associated Phosphatase EC 3.1.3.16 EC 3.1.3.48 KAP1
Location (GRCh38)
14:54396849-54420218
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005192.4
Sequence length
841.0 nt
GC content
0.4162

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-211.70 kcal/mol
Thermodynamic ensemble
Free energy: -226.93 kcal/mol
Frequency: 0.0000
Diversity: 200.61
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...((((.((((((((.(((((........))))).))))...))))...(((((((((....))..)))))))..(((((((((((...(((((.(((((...(((((((((((((.(((....((.((((.((...((((((((...((.((((.......)))).))))))))))...)).)))).)).....))).)))))))((((((((((.(((...((((((......)))))).....(((..((((((..........((.((((.((.((((((....)))))).)).)))).))((((.((((......))))..))))....))))))..)))...(((......)))........(((.(((((...........))))).)))..(((...((((((.....)))))).......))).))).))))))))))....................((((.(((......))).)))).(((((.((((((((...((((((((.(((((((..........((((((........((....))........))))))((((.((.(((((...))).)))))))).....(((((((.(((..(......)..))).))).)))).)))))))..)))))))).((((.........)))).......))))))))...))))).....((...(((.(((.....))).)))))..))))))...)))))..)))..))....))))))))))).......))))..(((((..(((((((((((...((((....)))).))))))...)))))....)))))...
Thermodynamic Ensemble Prediction
.,.((((.((((((((.(((((........))))).)))),..})))...((((((({{....}}..)))))))..(((((((((((...(((((,,{{||}},|{{((((((((((,{{{,{,.((.((((.((...((((((((...((.((((.......)))).))))))))))...}).)))).)),.|,.}}}.)))))))(((((((({{.,,,...((((((......}))))).....{((,.((((((..........((.((((.((.((((((....)))))).)).)))).))((((.((,(......,,),}}))))....)))))).,))},{,({{.....,)))........(((.(((((........,..))))).)))..{{{,..((((((.....))))))......,))},}}},})))))))}),...................{{{,.,,,...,{{|}},||||,({{{{,((((((((..,((((((((.(((((((.........,((((((........{{....))....,...))))))|(((,{({{{(({...))).)))))))}.....{((((((.(((..{,.....},,))).))).)))}.)))))))..)))))))}..,||....,,..,)))}.......)))))))).,.,|,||||,..{{...(((.(((.....))).)))}}.,))))))...})))),,))),,)),...))))))))))).......)))).,{((((..(((((((((((...((((....)))).))))))...)))))....))))}...

Transcripts

ID Sequence Length GC content
NM_001130851.2 NCBI
ACCGGUGAGUCGCCGGCGCUGCAGAGGGAGGCGGCACUGGUCUCGACGU… 721 nt 0.4189
NM_001330173.2 NCBI
ACCGGUGAGUCGCCGGCGCUGCAGAGGGAGGCGGCACUGGUCUCGACGU… 934 nt 0.4165
NM_005192.4 NCBI
ACCGGUGAGUCGCCGGCGCUGCAGAGGGAGGCGGCACUGGUCUCGACGU… 841 nt 0.4162
Summary

The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Forensic Context

A study in human skin demonstrated that the CDKN3 was significantly up-regulated in thermally injured tissue compared to normal skin during the early wound repair process, as part of a broad analysis of 2,286 altered genes [Greco et al. DOI:10.1016/j.burns.2009.06.211]. A study in humans demonstrated that overfeeding induced up-regulation of the CDKN3 in abdominal subcutaneous adipose tissue [Shea et al. DOI:10.3945/ajcn.2008.25970].