Enables protein heterodimerization activity. Involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Located in cell surface and extracellular space. Biomarker of severe acute respiratory syndrome. [provided by Alliance of Genome Resources, Jul 2025]
Forensic Context
A study in human burn patients identified the CEACAM8 as one of 19 center genes that were commonly differentially expressed in blood samples from early-stage (<11 days postburn) and middle-stage (11-49 days postburn) patients compared to healthy controls, indicating its association with burn injury progression [Wu et al. DOI:10.007/s10753-018-0829-0].