Basic Information

Symbol
CHMP2A
RNA class
mRNA
Alias
Charged Multivesicular Body Protein 2A CHMP2 VPS2A BC-2 VPS2 Vacuolar Protein Sorting-Associated Protein 2-1 Putative Breast Adenocarcinoma Marker (32kD) Putative Breast Adenocarcinoma Marker BC-2 Chromatin Modifying Protein 2A Vps2-1 BC2 Charged Multivesicular Body Protein 2a VPS2 Homolog A (S. Cerevisiae) Chromatin-Modifying Protein 2a VPS2 Homolog A HVps2-1 CHMP2a
Location (GRCh38)
19:58551452-58555128
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_014453.4
Sequence length
894.0 nt
GC content
0.5582

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-306.40 kcal/mol
Thermodynamic ensemble
Free energy: -323.09 kcal/mol
Frequency: 0.0000
Diversity: 167.54
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((((...(((((.((((.(..(((..((..((((((((..(((((......((((.(..((.(.....).))..).))))(((((.((((..((((....)))).)).))))))).((((((((.(((((((........((((.....)))).((((.(....).))))..))))))))))..))))).))))))))))))).....((..(.(((((........))))).)..))............((((((..............((((.((((.......(((((......)))))....)))))))).(((((((..(((...((((((.((((((..........)))))))))))))))..)))))))((((....((((((((((((((((((..((((((((......)))......((..(((((....)))))..))(((((((.(((((((((((...)))))..(((....)))...((((((((((((((..(.....)..)))).)))).).))))).((...(((((................)))))...))..))).))).))))))).)))))..)))))...........((.(((....((((((((((((((.(((.....))))))))))...)))..))))....))).)).....(((((......)))))..........((((((.(((.(........).))).))))))(((.(((((....))))).)))))))))).)))))).....))))......)))).)).))..))).))))).)))))..)))).)))..((..(((....))))).(((((((..(((.......)))..)))))))............
Thermodynamic Ensemble Prediction
.(((((((...(((((.((({{(..(((..((..((((((((..(((((......((((.(..((,{.....).))..).))))((((,,((((..((((....)))).)).))))))).((((({((,{((((((.,.....{((((.....)))},((((.(....}.))))..))))))))))..))))).)))))}))))))).....(({{,.{((((........))))).)}.,}............((((((.........,}...((({.((((.......(((((......))))),,},,})))}}}.(((((((..(((,..{((((,,((((((..........}))))))))))))))..)))))))((((....((((((((((((((((((..((((((((..,,..}}}......((..(((((....)))))..})(((({{,.{{,,,,({{{{,,.))}}}..(((....)))...,(((((((((((((..{.....}..)))).)))).).)))){{((...((((({{.{,{..........,,.,}...}.,})))})))}),})))).)))))..)))))........,,,((.(((....((((((((((((({,(((.....))))))))))...)))..))))....))).))....,{((((......))))},}}......,((((((.(((.(........).))).)))))){((.(((((....))))).)))))))))).)))))).....))))......)))).)).))..))).))))).)))))..)))).)))....,{(({....,||||.(((((({..(((.......}))..}}})))),.,,,..,,,,.

Transcripts

ID Sequence Length GC content
NM_014453.4 NCBI
AAUCCGGAAACGGCGGCGGCGGCGACAGGACCGAGGGGCCUUAGUUGGU… 894 nt 0.5582
NM_198426.3 NCBI
AAUCCGGAAACGGCGGCGGCGGCGACAGGACCGAGGGGCCUUAGUUGGU… 1017 nt 0.5762
Summary

CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

Forensic Context

A study in humans using RNA-seq data from 16 normal tissues identified the CHMP2A as a housekeeping gene with highly uniform and strong expression across all examined tissues, proposing it for calibration in biotechnological applications and genomic studies due to its exceptionally constant expression level [Eisenberg and Levanon DOI:10.1016/j.tig.2013.05.010].