This gene encodes a member of the HNK-1 family of sulfotransferases. The encoded protein transfers sulfate to the C-4 hydroxyl of N-acetylgalactosamine residues in dermatan sulfate. Mutations in this gene have been associated with adducted thumb-clubfoot syndrome.[provided by RefSeq, Mar 2010]
Forensic Context
A study in mice demonstrated that formalin-induced inflammatory pain led to the upregulation of the CHST14 gene, which is involved in glycosaminoglycan biosynthesis, as part of the cortical transcriptomic response one hour after injury [Erdei et al. DOI:10.3390/ijms26083538].