Basic Information

Symbol
CMA1
RNA class
mRNA
Alias
Chymase 1 Chymase 1, Mast Cell Mast Cell Protease I Alpha-Chymase EC 3.4.21.39 Chymase CYH Chymase 1 Preproprotein Transcript E Chymase 1 Preproprotein Transcript I Chymase, Mast Cell Chymase, Heart EC 3.4.21 MCT1 CYM
Location (GRCh38)
14:24505353-24508265
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001836.5
Sequence length
937.0 nt
GC content
0.5229

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-301.60 kcal/mol
Thermodynamic ensemble
Free energy: -320.49 kcal/mol
Frequency: 0.0000
Diversity: 273.28
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((((((.((((((.......)))))).)))))))...(((((.(((((((..((((((((....(....)....)))))...))).))))))).....((((((...(((((.......)))))..))))))....((((....(((((........)))))..))))((.(((....))).)).((((((.((....)).)))))).(((...(((..((((.......))))....)))....)))(((..(((.((((((((((.(...((((..(((((......(((((.(((((((.........))))..))).)))))........((((((.(((..(((((.(((...............((((((((((((...((((((.......))))))..(((((...)))))......)))...)))))))))(((((((((((.(.....).))))))))..)))))).)))))..))).))))))......((.(((((..((((....((((((..((((((.((..(((....))))).)).))))))))))))))..)))))))....)))))..))))))))))))..))).)))..)))....((((.((((..((((.(((((((((((.......((((.(((((((.((((.((((..(((........(((((((.((..((...))..)).))))))).....)))...........(((((.((((.....)))).((((.(((((..........(((........))))))))...)))).)))))...((((((((((..(((.......)))..))))....)))))))))).))))))))))))))).......)))))))).))).))))..))))..))))...................)))))....
Thermodynamic Ensemble Prediction
,{{,((({({{(((,,{,,,,,|||||,|||}}}}.,,|({{{|(((((((..((((((((....{....}....)))))...))).))))))}.,,,.((((((...(((((.......)))))..))))))...,|({{.,,,(((((........)))))..)))}{{.({,....}}|,}},(({((((,.....||.||}}||,{{(,..{{{,,||||.....,.)))),..,|}},...,,,{{{..{{{.{(|{{{{||.|{|,.,{{{,,|{{{|......(((((.(((({((,.,,,....}}}}..}}}.}}}}}........,(((((.(((..(((((.(({,..............{((((((({((,{,.{((((({{.....}})))),.(((((...})))),,,...}}}...}))))))))|{{((((((((.{.....).)))))))).,))}))),)))))..))}.)))))}.....,{(.(((({..((((,...{(((((..((((((.{{,.(((....))))).)).))))))))))))))..))))))).,..})))).,))))))))))))..))),)))..)))....{(((.{{{{..((((.(((((((((((.......((((.(((((((.((((.((((,...({,....||{({{(((.((.,({...))..}}.)))}}}|,{..,,|,...,,{,,,{.{,{(({{{(({((.....)}}||..{{|||..........|||,|,..,..|||||}|}..,})}..}))))...{(({{{((((..(({.......}))..))))...,)))))))))).))))))))))))))).......))))))))},)).))))..))))..)))}...........,}}}.,||}}},,}.,.

Transcripts

ID Sequence Length GC content
NM_001308083.2 NCBI
AGCAUUUGCUCAGGCAGCCUCUCUGGGAAGAUGCUGCUUCUUCCUCUCC… 786 nt 0.5254
NM_001836.5 NCBI
AGCAUUUGCUCAGGCAGCCUCUCUGGGAAGAUGCUGCUUCUUCCUCUCC… 937 nt 0.5229
Summary

This gene encodes a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Alternative splicing results in multiple variants. [provided by RefSeq, Apr 2015]

Forensic Context

A study in human dermal injuries demonstrated that the CMA1 (CMA1) mRNA expression was reproducibly detected but strictly limited to the 0–2 minute post-injury time point, showing a time-restricted pattern useful for forensic injury age estimation when used in combination with other markers [Palagummi et al. DOI:10.1007/S00414-013-0941-5]. A systematic review of human skin wounds from forensic autopsies identified the CMA1 as a proteomic marker of mast cells, with its density being higher in vital lesions compared to post-mortem wounds, indicating its application for vitality differentiation [Ros et al. DOI:10.3389/fmed.2021.786798].