Basic Information
Symbol
circSPECC1
RNA Class
circRNA
Alias
Sperm Antigen With Calponin Homology And Coiled-Coil Domains 1
HCMOGT-1
CYTSB
NSP
Cytokinesis And Spindle Organization B
Nuclear Structure Protein 5
Sperm Antigen HCMOGT-1
Cytospin-B
FLJ36955
NSP5
Sperm Antigen With Calponin-Like And Coiled Coil Domains 1
Structure Protein NSP5a3a
Structure Protein NSP5a3b
Structure Protein NSP5b3a
Structure Protein NSP5b3b
Sperm Antigen HCMOGT 1
Cytospin B
HCMOGT1
Location (GRCh37)
17:20107646-20109225
UCSC Genome Browser
Location (GRCh38)
17:20204333-20205912
Host gene
SPECC1
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_SPECC1_0010300 | Exon-Exon | chr17:20107646-20109225 | chr17:20204333-20205912 | 1580 nt | 0.4576 |
Forensic Context
A study in humans demonstrated that the circSPECC1 is a diagnostic biomarker for ischemic stroke, showing up-regulation in patient peripheral blood with a log2 fold change of 2.025537 and host gene SPECC1 [Wei et al. DOI:10.1186/s12883-021-02397-0]. Quantitative real-time PCR validation confirmed its up-regulated expression pattern, and receiver operating characteristic curve analysis indicated a diagnostic area under the curve of 0.800, supporting its relatively high diagnostic value.