Basic Information
Symbol
circTPCN1
RNA Class
circRNA
Alias
Two Pore Segment Channel 1
TPC1
KIAA1169
Voltage-Dependent Calcium Channel Protein TPC1
Two Pore Calcium Channel Protein 1
Two Pore Channel Protein 1
FLJ20612
Two-Pore Channel 1, Homolog
Location (GRCh37)
12:113663049-113736389
UCSC Genome Browser
Location (GRCh38)
12:113225244-113298584
Host gene
TPCN1
Host category
mRNA
Forensic tag(s)
Mechanical injury analysis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TPCN1_0000200 | Exon-Exon | chr12:113664533-113698297 | chr12:113226728-113260492 | 362 nt | 0.5691 |
| hsa_TPCN1_0002400 | Exon-Exon | chr12:113703985-113710497 | chr12:113266180-113272692 | 546 nt | 0.5989 |
| hsa_TPCN1_0002500 | Exon-Exon | chr12:113703985-113711095 | chr12:113266180-113273290 | 605 nt | 0.5901 |
| hsa_TPCN1_0002700 | Exon-Exon | chr12:113705648-113707650 | chr12:113267843-113269845 | 334 nt | 0.5928 |
| hsa_TPCN1_0002800 | Exon-Exon | chr12:113705648-113710497 | chr12:113267843-113272692 | 369 nt | 0.5854 |
| hsa_TPCN1_0002900 | Exon-Exon | chr12:113705648-113711095 | chr12:113267843-113273290 | 428 nt | 0.5748 |
| hsa_TPCN1_0003000 | Exon-Exon | chr12:113705648-113715169 | chr12:113267843-113277364 | 770 nt | 0.5597 |
| hsa_TPCN1_0003100 | Exon-Exon | chr12:113705648-113716042 | chr12:113267843-113278237 | 819 nt | 0.5507 |
| hsa_TPCN1_0003200 | Exon-Exon | chr12:113705648-113716640 | chr12:113267843-113278835 | 883 nt | 0.5481 |
| hsa_TPCN1_0003300 | Exon-Exon | chr12:113705648-113724899 | chr12:113267843-113287094 | 1220 nt | 0.5451 |
Showing 1 to 10 of 90 entries
Forensic Context
A study in human traumatic brain injury (TBI) patients identified the circTPCN1 as a top up-regulated circular RNA (fold change 19.03) in brain injury tissues compared to adjacent contusion tissues, with its differential expression validated by qRT-PCR [Li et al. DOI:10.3389/fneur.2022.1086553]. The broader literature indicates that circular RNAs exhibit tissue-specific expression and can function as miRNA sponges, transcriptional regulators, and biomarkers for various conditions, including neurological disorders [Sema Misir et al. DOI:10.1038/s41418-022-00948-7].