Basic Information
Symbol
circTPCN1
RNA Class
circRNA
Alias
Two Pore Segment Channel 1
TPC1
KIAA1169
Voltage-Dependent Calcium Channel Protein TPC1
Two Pore Calcium Channel Protein 1
Two Pore Channel Protein 1
FLJ20612
Two-Pore Channel 1, Homolog
Location (GRCh37)
12:113663049-113736389
UCSC Genome Browser
Location (GRCh38)
12:113225244-113298584
Host gene
TPCN1
Host category
mRNA
Forensic tag(s)
Mechanical injury analysis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TPCN1_0003400 | Exon-Exon | chr12:113705648-113728048 | chr12:113267843-113290243 | 1498 nt | 0.5461 |
| hsa_TPCN1_0003500 | Exon-Exon | chr12:113705648-113729482 | chr12:113267843-113291677 | 1614 nt | 0.5428 |
| hsa_TPCN1_0003900 | Exon-Exon | chr12:113706547-113706677 | chr12:113268742-113268872 | 131 nt | 0.6260 |
| hsa_TPCN1_0004000 | Exon-Exon | chr12:113706547-113716042 | chr12:113268742-113278237 | 705 nt | 0.5461 |
| hsa_TPCN1_0004100 | Exon-Exon | chr12:113706547-113724899 | chr12:113268742-113287094 | 1106 nt | 0.5416 |
| hsa_TPCN1_0004200 | Exon-Exon | chr12:113706547-113728048 | chr12:113268742-113290243 | 1384 nt | 0.5434 |
| hsa_TPCN1_0004400 | Exon-Exon | chr12:113707562-113722576 | chr12:113269757-113284771 | 794 nt | 0.5164 |
| hsa_TPCN1_0004900 | Exon-Exon | chr12:113710463-113711095 | chr12:113272658-113273290 | 94 nt | 0.5106 |
| hsa_TPCN1_0005000 | Exon-Exon | chr12:113710463-113711473 | chr12:113272658-113273668 | 194 nt | 0.5155 |
| hsa_TPCN1_0005100 | Exon-Exon | chr12:113710463-113714840 | chr12:113272658-113277035 | 311 nt | 0.5177 |
Showing 11 to 20 of 90 entries
Forensic Context
A study in human traumatic brain injury (TBI) patients identified the circTPCN1 as a top up-regulated circular RNA (fold change 19.03) in brain injury tissues compared to adjacent contusion tissues, with its differential expression validated by qRT-PCR [Li et al. DOI:10.3389/fneur.2022.1086553]. The broader literature indicates that circular RNAs exhibit tissue-specific expression and can function as miRNA sponges, transcriptional regulators, and biomarkers for various conditions, including neurological disorders [Sema Misir et al. DOI:10.1038/s41418-022-00948-7].