Basic Information
Symbol
circTPCN1
RNA Class
circRNA
Alias
Two Pore Segment Channel 1
TPC1
KIAA1169
Voltage-Dependent Calcium Channel Protein TPC1
Two Pore Calcium Channel Protein 1
Two Pore Channel Protein 1
FLJ20612
Two-Pore Channel 1, Homolog
Location (GRCh37)
12:113663049-113736389
UCSC Genome Browser
Location (GRCh38)
12:113225244-113298584
Host gene
TPCN1
Host category
mRNA
Forensic tag(s)
Mechanical injury analysis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TPCN1_0000900 | Intron-Intron | chr12:113670001-113670394 | chr12:113232196-113232589 | 394 nt | 0.6193 |
| hsa_chr12_0099900 | Intergenic-Intergenic | chr12:113675538-113676245 | chr12:113237733-113238440 | 708 nt | 0.4788 |
| hsa_TPCN1_0001100 | Intron-Exon-Intron | chr12:113683717-113698297 | chr12:113245912-113260492 | 277 nt | 0.5848 |
| hsa_TPCN1_0001000 | Intron-Exon-Intron | chr12:113683717-113704161 | chr12:113245912-113266356 | 250 nt | 0.4960 |
| hsa_TPCN1_0001200 | Intron-Intron | chr12:113686785-113687022 | chr12:113248980-113249217 | 238 nt | 0.5882 |
| hsa_TPCN1_0001300 | Intron-Intron | chr12:113690164-113690473 | chr12:113252359-113252668 | 310 nt | 0.5742 |
| hsa_TPCN1_0001400 | Intron-Intron | chr12:113694405-113695083 | chr12:113256600-113257278 | 679 nt | 0.3873 |
| hsa_TPCN1_0001600 | Exon-Exon | chr12:113698173-113704161 | chr12:113260368-113266356 | 125 nt | 0.6080 |
| hsa_TPCN1_0001700 | Exon-Exon | chr12:113698173-113707650 | chr12:113260368-113269845 | 95 nt | 0.5684 |
| hsa_TPCN1_0001800 | Exon-Exon | chr12:113698173-113710497 | chr12:113260368-113272692 | 35 nt | 0.5143 |
Showing 41 to 50 of 90 entries
Forensic Context
A study in human traumatic brain injury (TBI) patients identified the circTPCN1 as a top up-regulated circular RNA (fold change 19.03) in brain injury tissues compared to adjacent contusion tissues, with its differential expression validated by qRT-PCR [Li et al. DOI:10.3389/fneur.2022.1086553]. The broader literature indicates that circular RNAs exhibit tissue-specific expression and can function as miRNA sponges, transcriptional regulators, and biomarkers for various conditions, including neurological disorders [Sema Misir et al. DOI:10.1038/s41418-022-00948-7].