Basic Information
Symbol
circTPCN1
RNA Class
circRNA
Alias
Two Pore Segment Channel 1
TPC1
KIAA1169
Voltage-Dependent Calcium Channel Protein TPC1
Two Pore Calcium Channel Protein 1
Two Pore Channel Protein 1
FLJ20612
Two-Pore Channel 1, Homolog
Location (GRCh37)
12:113663049-113736389
UCSC Genome Browser
Location (GRCh38)
12:113225244-113298584
Host gene
TPCN1
Host category
mRNA
Forensic tag(s)
Mechanical injury analysis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TPCN1_0001900 | Exon-Exon | chr12:113698173-113716640 | chr12:113260368-113278835 | 70 nt | 0.5286 |
| hsa_TPCN1_0001500 | Exon-Exon | chr12:113698173-113722442 | chr12:113260368-113284637 | 1287 nt | 0.5579 |
| hsa_TPCN1_0002000 | Exon-Exon | chr12:113698173-113722576 | chr12:113260368-113284771 | 179 nt | 0.5754 |
| hsa_TPCN1_0002100 | Exon-Exon | chr12:113698205-113723719 | chr12:113260400-113285914 | 339 nt | 0.5221 |
| hsa_chr12_0100100 | Intergenic-Intergenic | chr12:113701505-113707680 | chr12:113263700-113269875 | 250 nt | 0.4560 |
| hsa_TPCN1_0002200 | Intron-Intron | chr12:113702253-113702866 | chr12:113264448-113265061 | 614 nt | 0.4609 |
| hsa_TPCN1_0002300 | Intron-Intron | chr12:113702420-113702675 | chr12:113264615-113264870 | 256 nt | 0.3633 |
| hsa_TPCN1_0002600 | Exon-Exon | chr12:113703985-113707650 | chr12:113266180-113269845 | 220 nt | 0.6000 |
| hsa_TPCN1_0003600 | Intron-Exon-Intron | chr12:113705648-113707675 | chr12:113267843-113269870 | 120 nt | 0.5917 |
| hsa_TPCN1_0003700 | Exon-Exon | chr12:113705648-113711473 | chr12:113267843-113273668 | 120 nt | 0.5750 |
Showing 51 to 60 of 90 entries
Forensic Context
A study in human traumatic brain injury (TBI) patients identified the circTPCN1 as a top up-regulated circular RNA (fold change 19.03) in brain injury tissues compared to adjacent contusion tissues, with its differential expression validated by qRT-PCR [Li et al. DOI:10.3389/fneur.2022.1086553]. The broader literature indicates that circular RNAs exhibit tissue-specific expression and can function as miRNA sponges, transcriptional regulators, and biomarkers for various conditions, including neurological disorders [Sema Misir et al. DOI:10.1038/s41418-022-00948-7].