Basic Information
Symbol
circTTC3
RNA Class
circRNA
Alias
Tetratricopeptide Repeat Domain 3
RNF105
DCRR1
TPRDIII
TPRD
RING-Type E3 Ubiquitin Transferase TTC3
Tetratricopeptide Repeat Protein 3
E3 Ubiquitin-Protein Ligase TTC3
RING Finger Protein 105
TPR Repeat Protein 3
TPR Repeat Protein D
TPRDII
TPRDI
Protein DCRR1
EC 2.3.2.27
Location (GRCh37)
21:38445709-38575408
UCSC Genome Browser
Location (GRCh38)
21:37073409-37203107
Host gene
TTC3
Host category
mRNA
Forensic tag(s)
Forensic psychiatry evaluation
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TTC3_0009800 | Intron-Exon-Intron | chr21:38471924-38511014 | chr21:37099624-37138714 | 81 nt | 0.4444 |
| hsa_TTC3_0009900 | Intron-Exon-Intron | chr21:38471924-38536517 | chr21:37099624-37164215 | 101 nt | 0.4059 |
| hsa_chr21_0073800 | Intergenic-Intergenic | chr21:38473806-38474322 | chr21:37101506-37102022 | 517 nt | 0.2940 |
| hsa_TTC3_0010000 | Intron-Intron | chr21:38473862-38474068 | chr21:37101562-37101768 | 207 nt | 0.3430 |
| hsa_TTC3_0010100 | Intron-Intron | chr21:38479300-38479625 | chr21:37107000-37107325 | 326 nt | 0.3252 |
| hsa_TTC3_0013000 | Exon-Exon | chr21:38480692-38495328 | chr21:37108392-37123028 | 52 nt | 0.3462 |
| hsa_TTC3_0013100 | Exon-Exon | chr21:38480692-38497042 | chr21:37108392-37124742 | 55 nt | 0.4545 |
| hsa_TTC3_0013200 | Exon-Intron | chr21:38480692-38501381 | chr21:37108392-37129081 | 64 nt | 0.2813 |
| hsa_TTC3_0013300 | Exon-Intron | chr21:38480692-38506115 | chr21:37108392-37133815 | 144 nt | 0.4722 |
| hsa_TTC3_0013400 | Exon-Exon | chr21:38480692-38516945 | chr21:37108392-37144645 | 55 nt | 0.4545 |
Showing 141 to 150 of 299 entries
Forensic Context
A study in humans demonstrated that the circTTC3 shows a significant decrease in the peripheral blood of Alzheimer's disease patients, suggesting its potential to distinguish this condition from other dementias [Misir et al. DOI:10.1038/s41418-022-00948-7]. In mice and rats, circTTC3 was markedly upregulated in ischemic myocardium post-myocardial infarction and counteracted hypoxia-induced ATP depletion and apoptotic death in cardiomyocytes via the miR-15b/Arl2 axis [Tian et al. DOI:10.3390/molecules26041155]. It also alleviated hypoxic injury in HaCaT cells via miR-449a/NF-κB and PI3K/AKT pathways [Huang et al. DOI:10.3390/cells11091381].