Basic Information
Symbol
circTTC3
RNA Class
circRNA
Alias
Tetratricopeptide Repeat Domain 3
RNF105
DCRR1
TPRDIII
TPRD
RING-Type E3 Ubiquitin Transferase TTC3
Tetratricopeptide Repeat Protein 3
E3 Ubiquitin-Protein Ligase TTC3
RING Finger Protein 105
TPR Repeat Protein 3
TPR Repeat Protein D
TPRDII
TPRDI
Protein DCRR1
EC 2.3.2.27
Location (GRCh37)
21:38445709-38575408
UCSC Genome Browser
Location (GRCh38)
21:37073409-37203107
Host gene
TTC3
Host category
mRNA
Forensic tag(s)
Forensic psychiatry evaluation
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TTC3_0019900 | Exon-Exon | chr21:38516825-38525577 | chr21:37144525-37153277 | 968 nt | 0.3647 |
| hsa_TTC3_0020000 | Exon-Exon | chr21:38516825-38534365 | chr21:37144525-37162063 | 1398 nt | 0.3720 |
| hsa_TTC3_0020200 | Exon-Exon | chr21:38516825-38536517 | chr21:37144525-37164215 | 57 nt | 0.3333 |
| hsa_TTC3_0020300 | Exon-Exon | chr21:38516861-38520947 | chr21:37144561-37148647 | 310 nt | 0.3677 |
| hsa_chr21_0074000 | Intergenic-Intergenic | chr21:38516864-38520925 | chr21:37144564-37148625 | 285 nt | 0.3789 |
| hsa_chr21_0074100 | Intergenic-Intergenic | chr21:38518212-38519441 | chr21:37145912-37147141 | 1230 nt | 0.4561 |
| hsa_TTC3_0020400 | Intron-Exon-Intron | chr21:38519065-38520947 | chr21:37146765-37148647 | 941 nt | 0.3624 |
| hsa_TTC3_0020700 | Exon-Exon | chr21:38519781-38522470 | chr21:37147481-37150170 | 318 nt | 0.3648 |
| hsa_TTC3_0020900 | Exon-Exon | chr21:38519781-38525577 | chr21:37147481-37153277 | 847 nt | 0.3625 |
| hsa_TTC3_0021000 | Exon-Exon | chr21:38519814-38520947 | chr21:37147514-37148647 | 192 nt | 0.3646 |
Showing 221 to 230 of 299 entries
Forensic Context
A study in humans demonstrated that the circTTC3 shows a significant decrease in the peripheral blood of Alzheimer's disease patients, suggesting its potential to distinguish this condition from other dementias [Misir et al. DOI:10.1038/s41418-022-00948-7]. In mice and rats, circTTC3 was markedly upregulated in ischemic myocardium post-myocardial infarction and counteracted hypoxia-induced ATP depletion and apoptotic death in cardiomyocytes via the miR-15b/Arl2 axis [Tian et al. DOI:10.3390/molecules26041155]. It also alleviated hypoxic injury in HaCaT cells via miR-449a/NF-κB and PI3K/AKT pathways [Huang et al. DOI:10.3390/cells11091381].