| ID | Sequence | Length | GC content |
|---|---|---|---|
| AUCUGGCCCCUGGGCAGCUGCCCGGGGAGGCGGCCAGCGAGCUGGGGCC… | 1856 nt | 0.5490 | |
| AUCUGGCCCCUGGGCAGCUGCCCGGGGAGGCGGCCAGCGAGCUGGGGCC… | 1757 nt | 0.5492 |
This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor that regulates G1/S transition in the cell cycle, and epidermal growth factor receptor/protein kinase B signaling during tumor pathogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
A study in mouse primary cortical astrocytes demonstrated that brief ethanol exposure significantly activated the CMTM7 alongside numerous other inflammatory-immune response genes, as part of a broad transcriptional response mediated by heat shock factor 1 (HSF1) via the heat shock pathway [Pignataro et al. DOI:10.1002/Brb3.125].