Basic Information
Symbol
COPS9
RNA class
mRNA
Alias
COP9 Signalosome Subunit 9
CSNAP
CSN Acidic Protein
MYEOV2
Myeloma-Overexpressed Gene 2 Protein
COP9 Signalosome Complex Subunit 9
Myeloma Overexpressed 2
Helicase/Primase Complex Protein
Location (GRCh38)
2:240126563-240136807
Forensic tag(s)
Drug abuse diagnoses
MANE select
Transcript ID
NM_001163424.2
Sequence length
418.0 nt
GC content
0.5263
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-135.50 kcal/mol
Thermodynamic ensemble
Free energy:
-145.39 kcal/mol
Frequency:
0.0000
Diversity:
106.57
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
......(((((((((..(.....)..))).))))))((((...((((...(((((((.....))))).))((((...(((((((((.(.((((.((((.((((((((.(.((.((((((.(((........)))(((.(((.((((..(((((((.....)))))))....))))))))))....((((......))))(((((((....)))).))))))))).)).).)...)))))).).))))..)))).).((((....(((((.(((...........))).)))))....)))).(((((((..((((....)))).....(((((....)))))....)))))))(((((((((((....)))))))))))..)))))))))....))))..........)))).)))).
Thermodynamic Ensemble Prediction
......(((((((((..(.....)..)))}})))))((((,..{{{({{.(((((((.....))))).)).))|..,(((((({(({{.((((.((((.((((((({,{.((.((((((.(((........))),((,,,.,|,|,,,|{||{{,.....,}}}}}|{{{{.||||,{|{{....}}}|}}}.}}))),(((((((....)))).))))))))).)).,.,,..)))))).).))))..)))).)}}(((({{{(((((.(((,{{,....}},))).))}},..,{|{......,}}}..((((....)))).....,.,|}}}}}))),,..,{|||.,.{(((((((((((....)))))))))))),)))))))))....}}},...........,},.}})).
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| CUAGAGCGCCGCGGCCCCGAGAUGAAGCCGGCGGUGGACGAGAUGUUCC… | 418 nt | 0.5263 | |
| AUGUGGCGCGCGCCGGAAGCGGCUCUGAGGCCGGAAGUGAGCCUAGAGC… | 759 nt | 0.5731 |
Summary
Involved in cellular response to UV; negative regulation of protein neddylation; and positive regulation of cell population proliferation. Located in chromatin; cytoplasm; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Forensic Context
A study in rhesus macaques demonstrated that chronic ethanol self-administration is associated with broad transcriptomic changes in the brain, where the COPS9 was identified as a hub gene in the cortical Area 32 coexpression network, with its expression levels correlating with ethanol intake [Iancu et al. DOI:10.1111/Adb.12501].