Basic Information

Symbol
COX7C
RNA class
mRNA
Alias
Cytochrome C Oxidase Subunit 7C Cytochrome C Oxidase Subunit 7C, Mitochondrial Cytochrome C Oxidase Polypeptide VIIc Cytochrome C Oxidase Subunit VIIc Cytochrome-C Oxidase Chain VIIc
Location (GRCh38)
5:86617905-86621246
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001867.3
Sequence length
629.0 nt
GC content
0.4070

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-161.90 kcal/mol
Thermodynamic ensemble
Free energy: -174.31 kcal/mol
Frequency: 0.0000
Diversity: 184.11
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((((.(((((..(......)..))))).).))))))..(((((((((((((((((....))))))))((.(((((((.(((((((.....)))))))...((((((......))))))((....))....(((((((...)))))))(((((((...))).)))).))))))).)).(((((((((((((((....(((((((....((((.....((((((..((((((...((((((((....((((.......((((((((........))))))))......(((((....((((((....)))))))))))..))))....))))))))......((((((.((((((...)))))).))))))..(((((..(((...(((..((..(((...(((.(((((....))))).)))...)))...))...)))..)))..))))).(((((((..((((((.((((....(((((((..(....)..)))))))....)))))))))))))))))...))))))....))))))))))..)))))))......)))))))....)))))))).)))))))))......................................
Thermodynamic Ensemble Prediction
.{((((((.(((((..(....,.)..))))).}.))))}}...{.((((((((,{((((..{{|||||,,,((.(((((((.(((((((.....))))))},,,((((((......))))))|,...,))....(((((((...)))))))(((((((...}),,)))).))))))).)){((((((((,,,,,,..,.|||||}},}).....}}}}}}|,}|||}}.|}}}}}}},|(((({(,..,{{{,..,,,.,((((((((........)))))))}|..{,{((({(....((((((....))))))}))),{{{{,,{{{{{||,||||{{,{,,((((({.((((((...)))))).))))))..{{,,,..,||..,||||,{{{{{..,,{(((.{{{{({{,.,|....}})}}}},,...||.....)}.}},..,,,}}.(((((((..(((((,,((((....(((((((..,....}..)))))))....)))))))))))))))))...,,})),},}}))}})}))))))).,))))......,|||,||{{{{||}}},))))))))}))}}|}}}}..,,,.,.,,,,,,}}}}},,.,}},,,,...

Transcripts

ID Sequence Length GC content
NM_001867.3 NCBI
CUUUUCAGUCCUUGCGCACCGGGGAACAAGGUCGUGAAAAAAAAGGUCU… 629 nt 0.4070
Summary

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIc, which shares 87% and 85% amino acid sequence identity with mouse and bovine COX VIIc, respectively, and is found in all tissues. A pseudogene COX7CP1 has been found on chromosome 13. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans identified the COX7C as a mitochondrial-associated core gene through RNA sequencing and bioinformatics analysis of peripheral blood from sepsis patients and healthy controls [Li et al. DOI:10.1186/s12920-024-01891-x]. In a separate review of mouse and human studies on myocardial infarction, the COX7C was characterized as a marker for high-energy metabolic cardiomyocytes, being enriched in a specific ventricular cardiomyocyte cluster [Bian et al. DOI:10.3892/mmr.2025.13680].