Basic Information

Symbol
CRABP2
RNA class
mRNA
Alias
Cellular Retinoic Acid Binding Protein 2 CRABP-II Cellular Retinoic Acid-Binding Protein 2 Cellular Retinoic Acid-Binding Protein II RBP6
Location (GRCh38)
1:156699597-156708094
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Forensic psychiatry evaluation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001878.4
Sequence length
974.0 nt
GC content
0.5462

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-341.00 kcal/mol
Thermodynamic ensemble
Free energy: -359.45 kcal/mol
Frequency: 0.0000
Diversity: 197.18
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((.((((((.(.(((((((((((((.....(((((...((((.((((....))).).))))..))))).....))))))).)))))).)...)))))).)))))(((((((((((((.....)))......(((((((..........))))..))).......(((..(((((....))))))))...((((...(.(((((((((....(.((((((((.(((((((.((((((.(((.((......))..(((((((((.......((((((......))))))..........)))))).....)))))))))))).)))...))))..(((.(((((((((...((((((((((....(((.(.((((((((((((((((((((......(((.(.(((.((.......(((..((((((((...(((((...)))))((..(((((.....((((((..(((....))).)).)))))))))..))(((((((..(((.((((((.....)))))))))...)))))))...........(((((((((((..(((......(.(((....)))))))..)))))..))))))....)))).)))).))).......)).))))))).....)))))...(((.((((....((((((......))))))......)))))))))))))))))))))).).)))))))..)))))).)))))))))...)))......((((...((..(...((((((.((........)).)))))).).))...))))......)))))).)))..))))....))))).).))))(((((........(((((.((.(((((((...............))))))).))))))))))))..)))))))))).(((.......)))...............(((((.(((((....))))).)))))....
Thermodynamic Ensemble Prediction
.(((((.((((((.,,((((((((((((({({..(((({...((((.((((....))).).))))..)))))}}},.})))))).)))))).}...)))))}.)))))(((((((((((((.....)))...,,,...{(((.........,)))}..|||.......{{{..,,|||....}}}||{|,.,{((((...{.(((((((((....{.{{((((((,({,((((.((((((.(((.((......}}..({{((((((.......,{{((({,,...))))))..........)))))).....)))))))))))).}))}..})))..(((.(((((((((...(((((({{({....(((.(.((((((((((((((((((((.{,...(((.(.(((.((.......(((..((((((((...(((((...)))))((..(((((.....((((((..(((....))).)),}))))))))..))(((((((..(((.((((((.....)))))))})...))))))).........{.(((((((((((..(((......{.(((....)))))))..))))),.})))))}...)))),,))).))).......)).)))}))),,.,.)))))...{{{,{{((....((((((......)))))).,.,..)))},))))))))))))))))).).))))}})..)))))).)))))))))...)))......({((...((,.{...((((((.((........)).)))))).,.,,}.})))),.,...)))))).))}..))))}...})))),}.))))}|{{|,.,...,{(((((,((.(((((((....,......,.,,))))))).)),,}},.))))}})))))))))).,,,.......|||,.,,,,,.,,|,,,.{{{{{.,{{||....,}))).,}))),...

Transcripts

ID Sequence Length GC content
NM_001199723.2 NCBI
AUCCACUUACUAGCGCAGGAGAAGGCUAUCUCGGUCCCCAGAGAAGCCU… 1013 nt 0.5499
NM_001878.4 NCBI
AGCUUUGGGGUUGUCCCUGGACUUGUCUUGGUUCCAGAACCUGACGACC… 974 nt 0.5462
Summary

This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2010]

Forensic Context

A study in mice and rats demonstrated that the CRABP2 is a retinoic acid binding partner that delivers retinoic acid to RAR/RXR nuclear receptors and differentially regulates anxiety/depression-like behavior compared to FABP5 [Crofton et al. DOI:10.1016/J.Neuropharm.2020.108398].