Basic Information
Symbol
CXCR4
RNA class
mRNA
Alias
C-X-C Motif Chemokine Receptor 4
LESTR
Fusin
HM89
D2S201E
NPYY3R
HSY3RR
NPY3R
CD184
NPYR
Leukocyte-Derived Seven Transmembrane Domain Receptor
Lipopolysaccharide-Associated Protein 3
Stromal Cell-Derived Factor 1 Receptor
Chemokine (C-X-C Motif) Receptor 4
C-X-C Chemokine Receptor Type 4
LPS-Associated Protein 3
SDF-1 Receptor
CD184 Antigen
LAP-3
NPYRL
FB22
LCR1
Seven-Transmembrane-Segment Receptor, Spleen
Chemokine (C-X-C Motif), Receptor 4 (Fusin)
Seven Transmembrane Helix Receptor
Neuropeptide Y Receptor Y3
Neuropeptide Y3 Receptor
WHIMS1
CXC-R4
CXCR-4
WHIMS
LAP3
WHIM
Location (GRCh38)
2:136114349-136119177
Forensic tag(s)
Sudden cardiac death diagnosis
MANE select
Transcript ID
NM_003467.3
Sequence length
1668.0 nt
GC content
0.4580
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-468.30 kcal/mol
Thermodynamic ensemble
Free energy:
-503.08 kcal/mol
Frequency:
0.0000
Diversity:
644.69
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(.(((((((.((((....)))).))))))).).((((.((((..(((((..(((((....((.......(((((((((((((((((.(((.((((((.((.((.........((((((((((......((((((...((((.((((((((.((((.(((((((((((((.....((((((((((....................))))).(((((((.(((((..................))).)).))))))))))))..)))..))))..))))))))))(((((((.....(.(((((.(((..((((((....((((((........)))))).........)))))).))).)))))))))))))...((.((((.(((((...((((.(....(((((...))))).....).))))))))).)))).))..))))..((((....(((((((.((((..(((((........((.(((((.(((....)))....))))).))........)))))((((.(((((((((((.((.(((....(((((((..(((((((((.(((.....((......)).......))).))).........))))))(.((((..((.((((((((((....)))))((.(((..(((((((((....))).))))))..))).))..((...((((...((.((.((((..((((......))))..)))).))))...))))...)).....)))))))..)))).)........((((((.............))))))..)))))))..))).))..))...))))))))).))))....(((((((.........)))..))))...(((((...((((((.((.((.....)).))..)))))).))))))))).)))))))......((((....))))....))))))))))))))))))....)))))))))).........)))).)))))).)))))))............((((((.((.(((((((((((((((....))))))(((((.((((....((((......))))....)))))))))...(((((((.....(((.(..((((..........))))..)))).....)))))))(((((((...))))))).........((((((......))))))((((..((..(((.(((.(((((.((((((((.....((((....))))..)))))).))...))))).))).)))..))....))))(((((.....)))))......(((((.....))))).......))).)))))))).))))))....(((.(((..((((((((.....(((((((......(((((.........(((((..((((.(((((..(.(((.((.(((((.(((((((((.((.....))...))))..)))))....)))..)).)).)))..)..))))).))))))))))))))..))))))).....)))).))))..))))))(((((.(((..........))))))))....)))))))))))))......))..))))..)..)))))..))).).))))((((((((.((((((....)))))).))).)).)))........
Thermodynamic Ensemble Prediction
{.(((((((.((((....)))).))))))).|.{{((,({(({,((({(,.{{((({..{({...,,..((((((((((((((,{(,{({{(({((({{{,{,........,|{{{({{{{(,,,,..(((((,{{((({{(((((,.{{,((,,.{|||{,{||,.||}}}..|||||(((((,,,{....,}}}........}}}}}.(((((((.({{{{..................))).}}.))))))),,))),,|||.,}}}|,,|||||}}||,{((((((.....{.(((((,(((,,(({{{(....((((((........))))))...,,..,},})))),)}}.)))))})))))))|.{(({((((|{(((({{{(,{{{{...(((((({..,,,,,.{{{,(((|{{|{{|({({||.{{{.{(,{.,({((,,(((((({,(({{.....(((((((..,{,((,{{(((.(({...{|||,..,},,,}.}}......,.},..))))))}}))},))}))))},})}..}))),|,||,|||}}|||,,||||,..||||}.|..|||,,,...,}}}}}}..,||,,}}}}||,|||,.{(({{((|((,,{((((,.....,(({(({,(({,(((((((({....})).)))))).,|||{|,,,,...,||||},....((.((((..(({({.,,,,||}}..}}}}.}},|...(((....)))...........}}}}.}}}}}|.....((((((....,..,,,...)))))}.,{({,,,,{|||,..,......,|||,.,,.,.}})}}}}|,)}}||}}}}}.....}},,,}}))}}}}}}}|,..,.{{({,,,||{,,.,.,..,{{,||||{|{|}|,,}|||,,||}},}}....,|||||,,,},,...,.|||||}},.))))),,))}},,))}|})|}}},.|||,||{|,,|{||||||{{||||,.............{(((((.((,({({{{(({{{{{{|,|,|}}||}}((({,.{{{{....{{{{,,,,..)))),,,,)))))))}}...{({{{({.....{{|||,.{(((,{.....,.,|||||,,,||,,,,.|||}}||{((((({...})))))}},.,,....((((((......))))))...,...,,}|||,{{{{((((({({{((,,...},.}}}}}}}},},,)})),,))......))))))))),}}}.,}))}..})))|||||.....))))},.....{{{({.....,}})}...,...}))}))))),)),))))))}..,||}}||||.{{{{{,|{,,|||{{||||{.,,,,,,}}}},}}||,,.,||||,,,,,.,.||}}|,.({(((.,,....,)}}}}..,{{|.{...,,,}},},}|||{||,.,}|,,,|},..,,..(((({....})))){{{{{{|,,....,,..})))))))}}.,}))))})))}},)))),,.,,,..,,,..,,}}...,))))),,|,..,)))))))))))))....,.}}.||||||,|..,}))),,))),).))}}||{{{{({.((((((....)))))}.))).)).}))........
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| CUUCCCUCUAGUGGGCGGGGCAGAGGAGUUAGCCAAGAUGUGACUUUGA… | 1904 nt | 0.4364 | |
| AGUUUGUUGGCUGCGGCAGCAGGUAGCAAAGUGACGCCGAGGGCCUGAG… | 1881 nt | 0.4684 | |
| AGUUUGUUGGCUGCGGCAGCAGGUAGCAAAGUGACGCCGAGGGCCUGAG… | 1767 nt | 0.4669 | |
| AGCAGGAUUGGAAUCUUUUUCUCUGUGAGUCGAGGAGAAACGACUGGAA… | 1905 nt | 0.4719 | |
| AGUUUGUUGGCUGCGGCAGCAGGUAGCAAAGUGACGCCGAGGGCCUGAG… | 1668 nt | 0.4580 |
Summary
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] CIViC Summary for CXCR4 Gene
Forensic Context
A study in humans demonstrated that the CXCR4 was upregulated in CD8+ effector T cells from acute myocardial infarction patients without plaque rupture, where it was associated with plaque erosion and involved in angiogenesis and wound healing [Jun Qian et al. DOI:10.3389/fimmu.2022.908815].