This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Forensic Context
A single-cell transcriptomic analysis in a rat model of radiation-induced lung injury identified the ADORA2B as an orthologous rat gene associated with inflammatory processes [Shi et al. DOI:10.17305/bb.2024.10357].