DPEP2 belongs to the membrane-bound dipeptidase (EC 3.4.13.19) family. These enzymes hydrolyze a variety of dipeptides, including leukotriene D4, the beta-lactam ring of some antibiotics, and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (Habib et al., 2003 [PubMed 12738806]).[supplied by OMIM, Mar 2008]
Forensic Context
A study in human leukocytes from severe burn patients identified the DPEP2 as a top sustained increasing gene (SIG) with expression rising from the healthy state through the late recovery phase (>400 hours post-injury), classifying it as a core biomarker for burn recovery [Xu et al. DOI:10.1159/000493451].