Predicted to enable cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of DNA-templated transcription and transcription by RNA polymerase II. Located in several cellular components, including chromosome; cytosol; and nuclear lumen. Part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Jul 2025]
Forensic Context
A study in humans characterized the platelet transcriptome in patients with acute myocardial infarction (MI) and identified the ELL3 as having increased expression in platelets from patients with ST-segment elevation MI (STEMI) compared to non-STEMI (NSTEMI) [Eicher et al. DOI:10.3109/09537104.2015.1083543].