Basic Information

Symbol
EMP3
RNA class
mRNA
Alias
Epithelial Membrane Protein 3 (MAM Blood Group) YMP Epithelial Membrane Protein 3 Hematopoietic Neural Membrane Protein 1 HNMP-1 EMP-3 Protein YMP
Location (GRCh38)
19:48321310-48330560
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Individual identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001425.3
Sequence length
649.0 nt
GC content
0.5994

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-228.10 kcal/mol
Thermodynamic ensemble
Free energy: -240.02 kcal/mol
Frequency: 0.0000
Diversity: 122.00
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((((((((.(((((((...(((((........)).)))........((((((...(((..(((((((((((...(((.(((...(((((((((((((.((((........................)))....).)))))))..)).))))((((((.(((...))))))))).((((.........)))))))))).))))).))))))...)))(((((......(((((((((.(....(((((.((.....)).)))))....).)))))))))...)))))...............((((...(((((....(((((((((((..............)))).))).))))(((((((((...(((((.(((....))).(((.......))))))))(((((....(((((..........)))))...))))))))))))))..))))))))).))))))((((((((((.......((((((((((((((((.((((((.........)))))).)))))).)))....................)))))))(((((((.((...)))))))))))))))))))(((.......)))..))))))))).).).))))).......................
Thermodynamic Ensemble Prediction
(((((({((.(((((((...{({,(,.,.....}}.))}},......(((((({((((((((.,....,.))))......(((((((((((((((.....(({.......................{((...{{{{||(({.,..((({.,,((({{{.|||},.}))}}}))}....)))),.},,....)))))))},.))).}|((({{{..({(((((......(((((((((.{....(((((.((.....)).)))))....}.)))))))))...))))).}}.............|,.|......,.......,},,..}))}}),))}...))))).)))).)))))|((((((((...((({{.{({....|||.{{{..,,...,)))))))(((((....(((({..........}))))...))))))))))))),...)))},)}..})))))((((((((((.......((((((((((((((((.((((((.........,))))).)))))).)))............,......))))))))(((((((,({...)))))))))))))))))))(((.......)))..))))))))).).}.)))))...........,,........,,

Transcripts

ID Sequence Length GC content
NM_001313905.1 NCBI
CUAUCCAUUUCCUCCAGAAGAUGUCCAACAGUCACCAGUCUGGCAGCAG… 645 nt 0.5922
NM_001425.3 NCBI
GGAGGCCCGAGCGAGGGACAAGACUCCGACUCCAGCUCUGACUUUUUUC… 649 nt 0.5994
Summary

The protein encoded by this gene belongs to the PMP-22/EMP/MP20 family of proteins. The protein contains four transmembrane domains and two N-linked glycosylation sites. It is thought to be involved in cell proliferation, cell-cell interactions and function as a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Forensic Context

A study in rats demonstrated that the EMP3 is an orthologous gene associated with inflammatory processes in radiation-induced lung injury, identified via single-cell transcriptomic analysis [Shi et al. DOI:10.17305/bb.2024.10357]. In human subcutaneous adipose tissue, the EMP3 is part of a 38-gene obesity signature with a positive coefficient of 0.0701, and the overall signature score strongly correlates with body mass index and fat mass, including within monozygotic twin pairs, indicating its association is primarily environmental [Font-Clos et al. DOI:10.1088/1361-6579/aab85a].