Basic Information

Symbol
AKR1C3
RNA class
mRNA
Alias
Aldo-Keto Reductase Family 1 Member C3 PGFS Prostaglandin F Synthase KIAA0119 HSD17B5 HAKRB DDX 3-Alpha Hydroxysteroid Dehydrogenase, Type II Testosterone 17-Beta-Dehydrogenase 5 Chlordecone Reductase Homolog HAKRb Dihydrodiol Dehydrogenase X Dihydrodiol Dehydrogenase 3 3-Alpha-HSD Type II, Brain HA1753 DD3 Aldo-Keto Reductase Family 1, Member C3 (3-Alpha Hydroxysteroid Dehydrogenase, Type II) Trans-1,2-Dihydrobenzene-1,2-Diol Dehydrogenase Type IIb 3-Alpha Hydroxysteroid Dehydrogenase 17-Beta-Hydroxysteroid Dehydrogenase Type 5 3-Alpha-Hydroxysteroid Dehydrogenase Type 2 Hydroxysteroid (17-Beta) Dehydrogenase 5 Dihydrodiol Dehydrogenase Type I Indanol Dehydrogenase 3-Alpha-HSD Type 2 17-Beta-HSD 5 EC 1.1.1.210 EC 1.1.1.357 EC 1.1.1.188 EC 1.1.1.239 EC 1.1.1.53 EC 1.1.1.62 EC 1.1.1.64 EC 1.1.1.- EC 1.1.1 HluPGFS HAKRe DDH1 DD-3
Location (GRCh38)
10:5035354-5107686
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003739.6
Sequence length
1186.0 nt
GC content
0.4621

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-373.80 kcal/mol
Thermodynamic ensemble
Free energy: -395.80 kcal/mol
Frequency: 0.0000
Diversity: 252.69
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...(((((.((.((((......)))))).)))))........((((....))))...((((((((((((........(((((((.(((((.((((((((((.((.((((((((((.((..........)).)))))))))))).......(((......((.(((((((((...........((.((((((........)))))).))..(((((((((.((((((....(((....))).))))))....(((((.(((((......)))).).))))).((((((((((...........))))))))))))))))))).....))))..))))))).......)))((((.(((((..((((((((.((((((.....(((((((..(((((.....(((((((.((........)).(((((.((..(((..(((......)))..)))......)))))))..))))))))))))..))))))).....)))))).))).)))))..))))))))))))))))))).)))))..)))))))((((((((((.(((((.....(((((((((........(((((((..(((((((((.(.((((((.((((.........)))).....((((.((....)))))).......)))))).))))))))))..)))).)))(((((.((((...(((.((..((..(((.(........).))))).)))))...)))).)))))((.(((((((.((......)).))))))).))....(((((((....((.(((((((...))).)))).))))))))).))))))))).....(((......))).((((.((.....))..)))).((((((((.(((((.((.....)).).)))).)))))))).(((.((((.(((.(((((.....((((........))))....))))))))))))..)))(((((((((((((....))))))..(((((.(((((((...(((........)))))))))).))))))))))))......))))))))))))).)).(((((.........)))))...........)))))..)))))))((((.((((........)))))))).......(((((.((.((.......)).)).)))))......
Thermodynamic Ensemble Prediction
...(((((,((.{{((..,..,))}}}},||}}}..||||..,{{{..,,}))}...|{{|||||{{(({{......{((((((.(((((,((((((((((,((,((((((((((.((.,.....,..)).)))))))))),,.......,||..,,,..))||||||||},,.....,...{({((({((,,,.....})))))}))}}(((((((((.((((((....(({....})).))))))....(((((.{((((......)))).).))))).((((((((((...........))))))))))))))))))).||,,|||,..,}}},||,,,,...}||(((,{(((((..((((((((.(((((({{.{.(((((((..(((((.....(((((((.((.....,,.|}.{(((({{{..(((..(((......)))..)))..},,.,,}))))..))))))))))))..)))))))}.)}})))))).))).)))))..))))))))))))))))))).))))}..))))))|((((((((((.(((((.....((((((((,,.......(((((((..(((((((((.(.((((((.{(((,.,......}))),,...((((.{(....)})))).......)))))).))))))))))..)))).)))(((((.((((..{((({({..((..(((,{........),))})).)),))))})))).))))){(.(((((((.((......}).))))))).)}....(((((((....((.(((((((...))).)))).))))))))).))))))))).....(((......))).((((,((,..,.,,..}}}}.((((((((.(((((.{{.....)).}.)))).)))))))).{{(.((({{(((.(((((.....((((........))))....))))))))))))..}},{{{{(({((((((....))))))..(((((.(((((((,..{((........)))))))))).))))))}})))),.,},.))))))))))))).)),{|||{.||||..,,,}}}}..........,}}}}}},}|||||,((({{((((........)))))))),.,,))}||{,,.{{..,......,}},}}.,}}))......

Transcripts

ID Sequence Length GC content
NM_001253908.2 NCBI
GAAACAUUUGCUAGCCAGCUGAGUGACAGUGAUGGAUUCAAAACAUCAG… 1186 nt 0.4629
NM_001253909.2 NCBI
AAACAUUUGCUAGUCAGACAAGUGACAGGGAAUGGAUUCCAAACACCAG… 1026 nt 0.4035
NM_003739.6 NCBI
AAACAUUUGCUAGUCAGACAAGUGACAGGGAAUGGAUUCCAAACACCAG… 1186 nt 0.4621
Summary

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Forensic Context

A study in healthy young women using a monozygotic twin design demonstrated that mRNA expression of the AKR1C3 gene, an indicator of local androgen activation, was significantly higher in both whole adipose tissue and isolated adipocytes of heavier co-twins compared to their leaner sisters [Vihma et al. DOI:10.1016/j.steroids.2018.08.006]. In a separate human intervention study, the AKR1C3 gene was found to be downregulated in subcutaneous adipose tissue during short-term weight loss [Bollepalli et al. DOI:10.1038/ijo.2017.245].