Basic Information

Symbol
ANAPC11
RNA class
mRNA
Alias
Anaphase Promoting Complex Subunit 11 APC11 HSPC214 Apc11p Anaphase Promoting Complex Subunit 11 (Yeast APC11 Homolog) Hepatocellular Carcinoma-Associated RING Finger Protein Anaphase-Promoting Complex Subunit 11 Cyclosome Subunit 11 MGC882 APC11 Anaphase Promoting Complex Subunit 11 Homolog
Location (GRCh38)
17:81890669-81900991
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001002248.3
Sequence length
638.0 nt
GC content
0.5862

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-257.40 kcal/mol
Thermodynamic ensemble
Free energy: -270.48 kcal/mol
Frequency: 0.0000
Diversity: 213.27
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((((....))))))(((.(((((.(((((((((((((((((((.((((((....))))))((((((((.(((.(((((.(...((..(((...)))..))...).))))).)))(((((((...)))))))(((.(((((((((((((((((((((((....))))...))))).))).))).)))..))))...).)))..........((((...)))).(((((((((......)))))))))...))))))))....(((....((((.((((((((...)))))))).))))..))).((((((((((((.....)))).(((((.((.(((((..((((((....(((((((..(((...)))((((.....(((.(((((....((((.(((....)))))))....))))).))))))).)))))))....)))))).))))).))))))).(((....)))))))).)))..)))))))))......((((((((...))).))))).)))))))))))))))...(((((.((((((((((((.((.......)).)))))))).....)))).))))).(((((.........)))))....)))....................
Thermodynamic Ensemble Prediction
((((((....)))))){((.(((((.((((((((((((((((({{.((((((....)))))),,,{{,.,.||||(((({{({{.((.{((({{{|||..,|{{{|||||||{|||(((((((...}}})))||,,{,((((((((((((((((((((((....})))...))))}.))).))).}}),,}|)}.,..}}},.,,,,....,((({...})))|{((((((({|....,))))))))),},,,,,,,,||{.((((((((((({.,(((({(,...,))))))),)},..}))),}))))))|||,,....,})))|||(((.((.(((((..((((((....(((((({.,(((...)))|{{,....{(((.(((({....(({{|{((....)))))))....))))).))))}},.}))))))....)))))}.))))).))))))).{{{,...)}}))))}})}}..)))))))))|,...||.||||||,.,)})}))))))))))))))))))))),}.(((((.((((((((((((.((.......)).))))))),.,,.})})}.))))).|{{{{.........}}||},....,,.........,..........

Transcripts

ID Sequence Length GC content
NM_001289420.1 NCBI
CCGCACGCUCCGCCCGAUCGGCCAGGGCUGGGGGCGCUGGGGGCGCUAC… 1063 nt 0.6087
NM_016476.11 NCBI
GGGGAGGCGCGUGCGCACUGGCGUGCGAGACUCGGCGGGCGCUGUUGAG… 948 nt 0.5876
Showing 11 to 12 of 12 entries
Summary

Enables cullin family protein binding activity and ubiquitin-ubiquitin ligase activity. Contributes to ubiquitin-protein transferase activity. Involved in anaphase-promoting complex-dependent catabolic process; positive regulation of mitotic metaphase/anaphase transition; and protein polyubiquitination. Located in nucleolus and nucleoplasm. Part of anaphase-promoting complex. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulates the ANAPC11 in microglia, implicating it within the ubiquitin-mediated proteolysis pathway as part of the broader glial transcriptomic response to neurotoxic insult [Oladapo et al. DOI:10.3390/Ijms26020649].