Basic Information

Symbol
ASIP
RNA class
mRNA
Alias
Agouti Signaling Protein ASP AGTIL Agouti-Signaling Protein Agouti Switch Protein AGTI Agouti Signaling Protein, Nonagouti Homolog (Mouse) Agouti Signaling Protein, Nonagouti Homolog Agouti (Mouse)-Signaling Protein Nonagouti Homolog (Mouse) Nonagouti Homolog SHEP9 AGSW
Location (GRCh38)
20:34194569-34269346
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001672.3
Sequence length
653.0 nt
GC content
0.6018

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-258.60 kcal/mol
Thermodynamic ensemble
Free energy: -268.69 kcal/mol
Frequency: 0.0000
Diversity: 94.08
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
............(((((.....(((...(((((...)))))((((.(((......(((((....(((.((....)).))).......)))))....))).)))).(((.(((((((((((((((((.(((..(((((..((((.....(((((....(((((.(((((.........)))))...(((((..(((((...(((....))).))).))..))))).)))))...)))))))))........(((......))).)))))..))).))))))..........(((((...((((....))))...)))))....(((.((....)).)))((((..(((((((((((.(.((((.((((((.....)))..(((...)))(((((((((..(((.(((((((.(((((((((.((((.((.......)).)))).((((((.((((.(((((((((.......))))))))).........)))).).))))))))))))....)).).)))))).)))....)))))))))...........))).)))).).)))))).))))).))).)(((((((((.....))))))))).)))))))).)))..))).................))).....)))))..
Thermodynamic Ensemble Prediction
............(((((.....{{,...{((((...))))}((((.(((......(((((...,(((.((,,..}},)}).,},}..)))))..,.})).)))),(((.(((((((((((((((((.(((..(((((..((((.....(((((....(((((.(((((.........)))))...(((((..(((((...({{....})}.))).))..))))).)))))...)))))))))........{((......))).)))))..))).)))))}..........(((((...((((....))))...)))))..,.(((.((....)).))){{((,.(((((((((((.(.(({{.{{{{{....,,||,,{((({{{{{((((((((((..(((.((({(((,(((({.(((..,((.((.......)).))(((((((((.((((.(((((((((.......))))))))).........)))).).))))))))..)))...)))).)))))),)))....))))))))))..,,......,))})))),,.)))))).))))).))).}(((((((((.....))))))))),)))))))).)))..)))...................,.....)))))..

Transcripts

ID Sequence Length GC content
NM_001385218.1 NCBI
GCAUUUCGACUCAGCCCGCUGAACGCCUGGAAGAAAUUUUGCAGACCCA… 785 nt 0.5732
NM_001672.3 NCBI
AGCAAAUCUCUACAGCUGCAAGGUGAAAAAGGAAGUUCCUUGGCCUGGG… 653 nt 0.6018
Summary

In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. [provided by RefSeq, Jul 2008]

Forensic Context

No relevant information is available at the moment.