Basic Information

Symbol
ATF4
RNA class
mRNA
Alias
Activating Transcription Factor 4 CREB-2 TAXREB67 TXREB Tax-Responsive Enhancer Element-Binding Protein 67 Cyclic AMP-Dependent Transcription Factor ATF-4 Cyclic AMP-Responsive Element-Binding Protein 2 CAMP-Dependent Transcription Factor ATF-4 CAMP-Responsive Element-Binding Protein 2 Tax-Responsive Enhancer Element B67 CREB2 Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) CAMP Response Element-Binding Protein 2 DNA-Binding Protein TAXREB67 TaxREB67
Location (GRCh38)
22:39519695-39522690
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_182810.3
Sequence length
1419.0 nt
GC content
0.5321

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-495.40 kcal/mol
Thermodynamic ensemble
Free energy: -519.45 kcal/mol
Frequency: 0.0000
Diversity: 259.02
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..(((((((..(((((((.((((..(((((......)))))..)))).)).............((((.....((((...)))).....))))......)))))((((.(((((..((.((..(.(((........))).)..)).))..))))).))))(((.((........)).)))(((((((((((((((((.((....((((((.(((((...)))))..((......(((..((((..(((((((.....(((((.(((((((...((((.......(.((((....((((((((((..(.((((((((..((.(((((((.....)))))))..(((((.(((((((((..(((((......)))))((((.((......))..))))((((((((((((.........(((((.((((.(((((.(.(((.(((....(((((((((((((.....((((....((((.(((.........)))))))....))))..)))))).))))(((((..((((.......)))))))))(((.(((((..((((.(((((((.(((((((((....))))))........(((...)))...((((......)))).))).)))))))..).)))..))))).))))))..))).)))).)))))...............)))))).)))........))))))))))))..............)))))))))..)))))...))..)))))).......(((((((..((......((((((....((((((..((((..((((((((..((((...))))))).)))))..))))(((((((((.(((....((.((((((......))).....))).))....))).)))))).)))..))))))....))))))(((.....)))(((((((..((((..((.((((((......)))))).))(((........((((((((((((((((((((.......))))))))...(((((((((((......((((.(.....).))))......))).....)))))))).....)))))).))..........))))........)))......(((...........)))........))))..)))))))(((...)))))..))))))))).)..))))))))))....)))).))))).....)))))))........)))))((((...))))((((((((((.(((.....))).))))).)).)))....).)))))).))))..))).....))...((((((.........)))))).))))))....)).))))))))).))).))))).(((((.(((......))).)))))................)))))))..
Thermodynamic Ensemble Prediction
.....,......,,,(((.(((,,.(((((......))))),})),)})..{{((((...,,,((((,...,||{{...}|||.....)))).....)))),.((((.(((((..((.((..{.(((........))).}..)).))..))))).))))(((.((........)).))){((((((((((((((((.{({{..{{(((({((,{{,||))))|..}|,.....(((..((((..(((((({...,{(,((,.(((((((...((((.......(.((((....((((((((((..(.((((((((..((.(((((((.....)))))))..(((((.(((((((((,.(((((......))))),((({{,......)),,,,||((((((((((((....,{{..{((((.((((,(((((.(,({(.(((....(((((((((((((.....((((..{{((((.(((.........))))))).}}.))))..)))))).)))}{(((({{,{{,....,..)))))))))}.,.(((((..((({.(((((((.(((((((((....)))))).......{(((...,},..,|||{......))}}.))).)))))))..}.))}..))))).,,|})}..})}.)))}.))))),,.....,.,,....)))))).)))}}}.....)))))))))))),}}.........).)))))))))..)))))...))..)))))).......(((((((..{,......((((((....((((((..((((..((((((((..((({...})))))).)))))..))))(((((((((.(((,,,.((,((({((......)))}},..}},.))....))).)))))).)))..))))))....))))))(((.....)))(((((((..((((..((.((((((......)))))).)){{{{{{,{..{((((((.....})))))}((((.....))))|{{|...((((((((,(,,....,((((.{.....}.))))...,..}})}....))))))))...},,))},,,||,.........}|||......}}.........}))),.......|,},,........))))..)))))))(((...))),}..))))))))).)..))))))))))....)))).})))).....)))))))..}}.}},,),}}((({...,}})|{{|{(((((.(((.....))).))))).}}.})}....,.}))))}.))))..))),.|,,,}|.,((((({.........)))))).))))}),,..)),))))))))),,)).))))}.(((((.(((......))).)))))....{{{{{....}}})))))))}.

Transcripts

ID Sequence Length GC content
NM_001675.4 NCBI
AGCCAUUUCUACUUUGCCCGCCCACAGAUGUAGUUUUCUCUGCGCGUGU… 2041 nt 0.5625
NM_182810.3 NCBI
CAUUUCUACUUUGCCCGCCCACAGAUGUAGUUUUCUCUGCGCGUGUGCG… 1419 nt 0.5321
Summary

This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]

Forensic Context

A study in rats and pigs demonstrated that the ATF4 exhibits analogous time-dependent expression patterns in skeletal muscle following contusion injury and is part of a molecular framework enabling cross-species injury time inference [Wang et al. DOI:10.1007/s00414-026-03727-y].