Basic Information

Symbol
AZU1
RNA class
mRNA
Alias
Azurocidin 1 HBP Heparin-Binding Protein HUMAZUR CAP37 AZAMP NAZC AZU Cationic Antimicrobial Protein CAP37 Cationic Antimicrobial Protein 37 Neutrophil Azurocidin Azurocidin HHBP
Location (GRCh38)
19:825097-832018
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001700.5
Sequence length
907.0 nt
GC content
0.6748

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-403.60 kcal/mol
Thermodynamic ensemble
Free energy: -417.72 kcal/mol
Frequency: 0.0000
Diversity: 233.51
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
......((((((((.((((((((((((...((((.((((..((((.((((((((((((..(((((..(((....))))))))..))))...))))))))))))..)))).))))..(((((.........)))))......((((..((....((((...((((((((((((......(((((.((((((...(((.(((((.(((....((((((...))).)))....))).))))).))).)))).)))))))((((........))))(((((((.......)))))))((.(((((((..(((......)))..))))))).))...)))))).))))))))))...)).)))).))))..))))))))...((((((....))))))..((((.((....)).))))..((((....))))..((((((((((((((((((((((........))).)))))))(.(((.((((.(((.((((((((((.(.((...((((((...((((.((((...))))...))))...)))))).)).).))))))......(((.((((....)))).))))))).))).)))).))).)...(.(((((((((.....))))))))).).(((((((((((.((((...((((.((........)))))))))))))).)))))))......))))))...))))))....((((....)))))).))))))...........(((((..(((((.(((....((((((((((.((.......((((((...(((.................)))))))))........)).)).)))))).)).))).))))).))))).((((((((...(((((..........)))))....)))))))).
Thermodynamic Ensemble Prediction
.......,....,,..(((((.((((((..((((((.((((((((..,({.(((((((..(((((..(((....))))))))..))))...{,{((,(((((((((({,.((({{{|,,.{.||{|,,,||{||||.||,.,(((.,(({{((({((,,,((({{{{|||||||}...(((((.((((((...(((.(((((.(((....((((({...}))},))....))).))))).))).)))).)))))))||||.,,,.,,,)))}(((((((,,,,,,,|}}}|}}{{.(((({{(..{{(,,,,,,|}||.}}}}}}},},...}}}}}}.))))}}})}}.....}))})}})))}},|,{{{{,...((((((....))))))..|)}}}||}}}},,.}})},}|||||}},|,{((.((((((((((((((((((((((........))),})))))){,(((,((((.(((.((((((((((.(.((...((((((...((((.((({...})))...))))...)))))).)).).))))))......(((.((((....)))).))))))).))).)))).))).)...(.(((((((((.....))))))))).),((((((((({((((((...((((.((........)))))))))))))).)))))))......))))))...)))))).}},{{{|,...}))).,}..(({{{{...,,,,,}}}|||},||||||}.|}}}.(((((((,,(,(..{{{{...))}),.}}},,,,}}}}},,.....,,}))}|},}})}.,...........))|}}}))),,,)))..}),.)))))))).))))))..))))))........))))).............

Transcripts

ID Sequence Length GC content
NM_001700.5 NCBI
CUGCCCCGCCAUGACCCGGCUGACAGUCCUGGCCCUGCUGGCUGGUCUG… 907 nt 0.6748
Summary

Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. This gene encodes a preproprotein that is proteolytically processed to generate a mature azurophil granule antibiotic protein, with monocyte chemotactic and antimicrobial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, Nov 2015]

Forensic Context

A study in humans identified the AZU1 as a key immune-related gene and potential biomarker for burn injury, showing it was significantly up-regulated in burn patients compared to controls in both external dataset validation and qRT-PCR analysis of clinical blood samples [Niu et al. DOI:10.1093/jbcr/irad050].