Basic Information

Symbol
BCL2L12
RNA class
mRNA
Alias
BCL2 Like 12 BCL2-Like 12 (Proline Rich) Bcl-2-Like Protein 12 Bcl-2 Related Proline-Rich Protein Bcl-2-Related Proline-Rich Protein Bcl2-L-12 BPR
Location (GRCh38)
19:49664622-49673916
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_138639.2
Sequence length
1064.0 nt
GC content
0.6118

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-439.30 kcal/mol
Thermodynamic ensemble
Free energy: -457.03 kcal/mol
Frequency: 0.0000
Diversity: 358.26
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
........(((((((((((........)))))))))))(((....)))((((((((((((........((((..((((..((((((.((.((((((............((((((((((((((((....(((.((((.((((....(((((.(((.....((((((((((((((.........))).)))))))))))((((.....)))).....))).)))))))))..)))).)))..))))))).....((.((........)).))...(((.....))).)))))))))...(((((((((((.((((((((((..((((........))))(((((((....((((..(((((....((((..((....)).))))...)))))..))))..((((((..((.(......)))..)))))).....((((((..((((((.((...)).))))))..........))))))........((((((.((((.((......)).))..((......))((((((.((.(((((.((.((((..((((((((..........((((...))))...((((((..((..(((...))).)).)))))).))).)))))..))))...((.((.(((((((((((((((((....)))...)))))))).))))..)).)).))..))...))))))).))))))..((((((....(((((((((((((((.(.(((......)))).))))).))).))))))))))))))).))))))...)))))))(((((((((.........)))))))))((((....)))))))).)))))).))))))))))).((((.(((((.((.((((.(........))))).))..((((......))))))))).))))........(((((((((.(((((............((((....))))..............))))).))))))))))))))).))))).)))..)))).))))........)))))..)))))))......................
Thermodynamic Ensemble Prediction
.((((,{.(((((((((((........)))))))))))(((....))|||||||,{{{{{,.....,.{{{{{{{{|||||{(((({(((({(((({,{{{(((((((((((({((((({(((({...(((.((((,((({,..,(((((.{((|,...{((({(((((({(({,,,.,,{,}}|,|||}}}}}}}}((((.....)))),.{{,|||{|}|||||||..}}}|.}}}..}}},}}}..|,,||}||||,,..({{(.{{...{{(.,.,,})).}},}}))))...(((((((((((.(((((({{(({{{{((....,.,.))))(((((((.,,.((((..(((((..{,({{{..((....)).}}))}..)))))..)))).,((({,{,{((,(,.....||},,}}}))}...{.(({{((,.((((((.((...)).))))))...,,.,,,|}}}}|||.......{{(((({({((.((......)}.)}..((......}}((((((.((.(((((.((.((((..((((((((..........((((...})))...((((((..((..{((...))}.)).)))))).))).)))))..))))...((.{({,((((((((((((((((....)))}..,))))))).)))),,.)}}).))..))...))))))).))))))..{((({{,{{{(,,((((((((((((.,,(((......)))).))))).))).)))))))))}))))).)}))))||,))))))}(((((((((.........))))))))).{((....)}))))),.)))))).))))))))))).,|||.|}|||,||,{{((,(.,,,....}))}|,}}.,|{((|,|,..}}}))}}})}})},...}},}.||,}}}},}))},.)))))}..}))}}}}}},}}},,})},.},,.,}}}}}})}},}}}))))|||||,||,..)))))))||{{{||,.,}}},,,,....},,,..,})))))),..,,..,..}}..},}}},,.

Transcripts

ID Sequence Length GC content
NM_001040668.2 NCBI
CCUUUCUACGCUGGGCCGGUUAUCGACCCGGCCCAGUGCGCAGGCGCGG… 1061 nt 0.6126
NM_001282516.2 NCBI
CCUUUCUACGCUGGGCCGGUUAUCGACCCGGCCCAGUGCGCAGGCGCGG… 791 nt 0.5689
NM_001282517.2 NCBI
CCUUUCUACGCUGGGCCGGUUAUCGACCCGGCCCAGUGCGCAGGCGCGG… 648 nt 0.5556
NM_001282519.2 NCBI
CCUUUCUACGCUGGGCCGGUUAUCGACCCGGCCCAGUGCGCAGGCGCGG… 840 nt 0.5690
NM_001282520.1 NCBI
AAGUAAGUAUCCCCACUUUCAGGGUAGCAUCCUCUUUCCCUAGUUAUUU… 1528 nt 0.5517
NM_001282521.2 NCBI
CCUUUCUACGCUGGGCCGGUUAUCGACCCGGCCCAGUGCGCAGGCGCGG… 612 nt 0.5637
NM_001385706.1 NCBI
CCUUUCUACGCUGGGCCGGUUAUCGACCCGGCCCAGUGCGCAGGCGCGG… 788 nt 0.5698
NM_138639.2 NCBI
CCUUUCUACGCUGGGCCGGUUAUCGACCCGGCCCAGUGCGCAGGCGCGG… 1064 nt 0.6118
Summary

This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Forensic Context

A study in cultured human aortic endothelial cells demonstrated that the BCL2L12 mRNA was one of eleven most-significantly regulated transcripts at 24 hours post-irradiation, functioning as a marker to differentiate unirradiated (0 Gy) samples from those exposed to X-ray doses of 1-10 Gy [Chopra et al. DOI:10.1038/s41598-022-24051-6].