Basic Information

Symbol
TBCA
RNA class
mRNA
Alias
Tubulin Folding Cofactor A Tubulin-Specific Chaperone A TCP1-Chaperonin Cofactor A CFA Epididymis Secretory Sperm Binding Protein Tubulin-Folding Cofactor A Chaperonin Cofactor A
Location (GRCh38)
5:77691166-77868780
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004607.3
Sequence length
661.0 nt
GC content
0.3964

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-142.8 kcal/mol
Thermodynamic ensemble
Free energy: -155.81 kcal/mol
Frequency: 0.0000
Diversity: 236.2
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.......(((((((...))))).))....(((((.(((..(((((((...((((...........)))).)).)).)))))).))((((.((......(((......))).......)).))))(((((((((.(((((((..(((((...((((.((((((((...((((((.......(((.(((...(((.....(((....((((....))))....))).((((((...(((..(((((((((............((((((((..((((((((....(((((....)))))..(((.(((((((((((((.....)))).))))..........((.(((.....)))))((((((.....((..((...((((((((((....)))))...))))).))))......))))))))))).)))(((((.......)))))))))))))))))(((((.(((((..(.(((((.(((......))).))))).)..))).)).)))))..........)))).............)))))))))..)))...))))))....)))...))).))).......)))))).)))))))).))))....)))))..)))))))))))))))).......((((.....))))...)))..
Thermodynamic Ensemble Prediction
.......(((((,(,{{|||||{{{,(,,..(({.(((..(({((((...((((...........)))).)).)).)))})).})},,|.,|..}}}}|||}...{,|}....,,..}}.})))|||||,,(({(({(((({{((((....((({,((,{,,,....,{|||...,....,,,.,,,..{((({..,{((({.{{,((,,.{,,,||{{{{{{{{(,,(((..,((({{((((,,,{{...,,,..({({(((({.(((.(((((((((({,(((((....)))))...,.,||.}}}}))}}|,}}}.,,,.|{{{{{{...,........((({{......))}}}.............,...}}}}}}|))}}}))),}}}..},}....)))))...))))),,...)))..)))))))))))......)),),)),))))))}},||}|||||},|}|||||}|||}}}|{{{||{.,||,{|{.{{|{||{||.,,.}))}}))))))),}}}}}}}}....,|||||||||..,,,..{||||,,....|{{{{.}},.},|.,,,,,,||||},,}}}}}},,.,,}}....}}}}}..})})}},,}}}})))),.....}}}}}....,}}.)})))))}.

Transcripts

ID Sequence Length GC content
NM_001297738.2 NCBI
CUAAAUAGCCGCAGCCUCUGCGCGUCGCCCUCCACGGUUACCCCGGCUC… 2428 nt 0.3291
NM_001297740.2 NCBI
CUAAAUAGCCGCAGCCUCUGCGCGUCGCCCUCCACGGUUACCCCGGCUC… 574 nt 0.3833
NM_004607.3 NCBI
CUAAAUAGCCGCAGCCUCUGCGCGUCGCCCUCCACGGUUACCCCGGCUC… 661 nt 0.3964
Summary

The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Forensic Context

A study in humans demonstrated that the TBCA exhibited a Gini impurity score of 0, being present in some pure peripheral blood samples and in one mixture containing blood while being absent in mixtures without blood, indicating its discriminatory power for body fluid classification [Shehata et al. DOI:10.1016/j.fsigen.2025.103343].