This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. [provided by RefSeq, Jul 2008]
Forensic Context
A study in mice demonstrated that perinatal glyphosate exposure induced significant differential expression of lncRNAs and mRNAs in hippocampal tissue, with the CCKAR identified as a potential target in a ceRNA network involving lncRNA NR_033538 and miRNAs miR-142b and Let-7c, which is implicated in the neurotoxicity mechanism [Fan et al. DOI:10.1002/jdn.10102].