This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. Alternative splicing results in multiple transcript variants. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Dec 2015]
Forensic Context
A study in mice demonstrated that spinal nerve ligation induced significant transcriptional changes in injured dorsal root ganglia, including a 10.00-fold upregulation of the CCKBR (Cckbr) [Wu et al. DOI:10.1177/1744806916629048].