Basic Information

Symbol
CD48
RNA class
mRNA
Alias
CD48 Molecule SLAMF2 BLAST MCD48 HCD48 BCM1 Signaling Lymphocytic Activation Molecule 2 CD48 Antigen (B-Cell Membrane Protein) B-Lymphocyte Activation Marker BLAST-1 Leukocyte Antigen MEM-102 BCM1 Surface Antigen SLAM Family Member 2 CD48 Antigen BLAST1 TCT.1 CD48 Molecule MEM-102
Location (GRCh38)
1:160678746-160711831
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001778.4
Sequence length
1097.0 nt
GC content
0.4403

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-326.10 kcal/mol
Thermodynamic ensemble
Free energy: -348.30 kcal/mol
Frequency: 0.0000
Diversity: 204.24
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..(((((((((.(.((...............)).).)))))))))....(((((((((((((((.(((((((....((((....))))..)))))))...((....)).(((.(.((((..((.(((((((.........))))))).))......)))).).)))...((((((((.(((.(((((((..((((((((...(((((((..(((((((((....((...((((((..(....)..)))))).)).))))))....((((((.(((............)))))))))...)))..))))))).)))))...)))..))))))).)))..((((((((((((...((((.......))))..((((((((.((...)).)))))))).......((((..(.((((((((((((........(((((....(((((..........)))))(((((.((........)).)))))..((((((((((((....))))))))....))))..(((((((((((((.(.((((.((.((((....)))).)).))))....(((((((....)))).)))........(((.((.(((........))).))))).......).)))))))))))))((((.......))))........)))))......((((.....))))......((((.((.((((((((((((((((((......))).))))))......)))))).))))).))))....)))))))((((((........((((((.((((....)))).))).)).)........))))))...((((..(((....))))))).))))).)..))))...))))).)))))))(((.......))).)))))))).......(((.((..(((..(((....)))..)))..)).)))..........((((((((..(((((.((........)))))))))))))))....)))))))))))))))............(((((..(((((((((((((((..(((.....)))...)))))))).))))))))))))..........
Thermodynamic Ensemble Prediction
..,((((((((,(,({........,...,,,)}.,.))))))))}....(((((((((((((((.(((((((.,..((((....))))..)))))))...((...,||{({{.,.(((({,,,.|||||||,},,.....|||||},,|,..,,..))))}},))}...((((((((.(((.(((((((..((((((({...(((((((..{{,((((({....((...((((((..{....}..)))))).)).))))))....((((((.(({............))}))))))...}))..))))))).)))))...)))..))))))).)))..((((((((((((...((((.......))))..((((((((.({...}).)))))))).......((((,.,.((((({((((((..,.((((((.......))))))...,,.......,,(((((.((........)).)))))..((((((((((((....)))))))}....))))..(((((((((((((.(,(({(,((.{{{{,...||||,||,||}}....(((((((....}))).)))........(((,({.{{{......,,))),))))),,.....}.))))))))))))){{{{,..,|,.|||,,,{|||..,,.))}}}},,((({.,,.,||}}.},}.,|(((.((.((((((((((((((({((......})).))))))......)))))).))))).))))....))))))}((((((,....,,.{{((((.((({....}))).)))).).,.,......))))))...((((..(((....))))))).))))).),.))))...))))).)))))))(((.......))).)))))))),,.,{..(((.((.,(((..(((....)))..))),.)).)))..,,..,..,((((((({.{(((({,((........)))))))))))))))}.,.)))))))))))))))....,,......(((((,.,((((((((((((((,,((,......,,}}})))))))).))))))))))))......,,..

Transcripts

ID Sequence Length GC content
NM_001256030.2 NCBI
CUUUUUCUAGCCAGGCUCUCAACUGUCUCCUGCGUUGCUGGGAAGUUCU… 1486 nt 0.5074
NM_001778.4 NCBI
CUUUUUCUAGCCAGGCUCUCAACUGUCUCCUGCGUUGCUGGGAAGUUCU… 1097 nt 0.4403
Summary

This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Forensic Context

A study in mice demonstrated that the CD48 was stably expressed at 2 days post-injury but significantly upregulated at 14 and 60 days following controlled cortical impact, identifying it as part of the microglial sensome and a component of a specialized inflammatory state that emerges during the subacute and chronic phases of traumatic brain injury [Izzy et al. DOI:10.3389/fncel.2019.00307].