The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A soluble form of this protein can bind to dendritic cells and inhibit their maturation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] CIViC Summary for CD83 Gene
Forensic Context
A study in mice demonstrated that the CD83 was significantly upregulated at 14 days post-injury in microglia isolated from brains after controlled cortical impact, identifying it as part of the IFNγ pathway during a specialized inflammatory state [Izzy et al. DOI:10.3389/fncel.2019.00307].