Basic Information

Symbol
CFHR1
RNA class
mRNA
Alias
Complement Factor H Related 1 FHR1 CFHL CFHL1P CFHR1P H36-1 H36-2 CFHL1 HFL1 HFL2 Complement Factor H-Related 1 Pseudogene Complement Factor H-Related Protein 1 H Factor (Complement)-Like 1 H Factor (Complement)-Like 2 H Factor-Like Protein 1 H-Factor-Like 1 FHL-1 FHR-1 H36 Complement Factor H-Related 1
Location (GRCh38)
1:196819314-196837159
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002113.3
Sequence length
1297.0 nt
GC content
0.3832

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-310.80 kcal/mol
Thermodynamic ensemble
Free energy: -339.00 kcal/mol
Frequency: 0.0000
Diversity: 364.86
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((......)))).........((..((((.....(((((......)))))......))))..))..(((((((((((((..((((((((......))))))))...((((((((..((((((((.(((.((((.(((...((((((((((((...((((.((((((.......((((.((((...(((((...........)))))...)))).)))).............(((((((((((((((((..(((((((.(((.....))).))))))))))).......((((..(((..............)))..))))...........(((((((.((((((....((((....))))....)))))).)))))))....))).))))))))))..((((((....))))))......(((((...)))))......((((((...))))))((((((((.......(((...(((.(((((......))))))))...))).((((........)))).......(((((.....))).))..))))))))...))).))))))).......(((((((...((((....))))))))))).)))))).....)))))))))))))...)))...))))))))........))))))))((((((((..(((((((((..(((((((..(((.......((((((.(((((.....((((.(((((....(((((.....))))).(((((((((((((((..........)))))))))))))))...(((..(.(((((..((((((.(((..............)))))))))))))).)....))).........(((....(((....((((....)))))))...)))((((((....))))))..)))))))))..((((...........))))))))).)))))).........)))....)))))))((((((.((((((..((.(((((((.(((....))).)))).))).))))))))..))))))))))))))).........((((((((((....))...)).)))))).((((((....(((.......)))......)))))).))))))))...))))))))......((((((..(((((.((((((((...((((.((((.....((((((......))))))...)))).))))...)))))))).)))))..))))))....))))).................(((..........)))........
Thermodynamic Ensemble Prediction
{{((,,,...}}||....,{..,{{..((((...,,(((((......))))).},...))))...{,,((,{,((((((((..{(((((((......}))))})).,,((((((((,.((((((((.{((.{(({,({(,..{((((((((({(...((({,(((((({{,,{,,{{,,.|||{.,}||||,.........,.|||}}..,||}},},||,,,,.........((((((((((({{{|{,.,(((((((.(((.....})).)))))))),,,.......{({(|.{{{,,{{{,.....}}})))..,||||...,},}...(((((((.((((((....((((....))))....)))))).))))))},,..,}).))))))))))..,{{{{{.,,,)))}}|...,||{{|,,||||||||,,.{{{((((({...}))))},{||||{{..,....{{{...(({{(((((......))))))}),,.}},.((((..{,....)))).,,,...,{(((.....))).},,,)))})))),..})).))))))).......{((((((...((((....})))))))))}.}}))))..,,.))))))})))}}}.,,))}...))))))))........))))))))((((((((..(({.({(((({...,,....,(({.,....((((((.(((((.....((((.(((((....(((((.....})))).(((((((((((((((..........)))))))))))))))..{(((..(,(((({..{(((({,|{{,,.,,......{||||||}}}}}}}}}),}..,,))},.....,,,{{,....||{....((({....}}}}}}}...|||{((({{....)))))}..))))))))}..((((........,..))))))))).))))))...})}}..}|...|}||,,,,(((((((.((((({..{{,|{{{(((.(((....))).)))}.}}).}}})))))..)))))))},||{(,(.,,{,...,||||||}||,,...||,,,,}.)))},,.|{{{{{....{{{.......,)).,....)))))),))))))))...))))))))......((((((..(((({.((((((((...((((.((({.....((((((......))))))...}))).))))...)))))))).}))))..))))))....))))).............,,..{{,........,,))),..,,,..

Transcripts

ID Sequence Length GC content
NM_001379306.1 NCBI
CAGUUAGUACACUGAAAUUCAAAGUCAUGCUCAUAACUGUUAAUGAAAG… 1246 nt 0.3876
NM_001379307.1 NCBI
CAGUUAGUACACUGAAAUUCAAAGUCAUGCUCAUAACUGUUAAUGAAAG… 1135 nt 0.3903
NM_001379308.1 NCBI
CAGUUAGUACACUGAAAUUCAAAGUCAUGCUCAUAACUGUUAAUGAAAG… 1132 nt 0.3905
NM_001379309.1 NCBI
CAGUUAGUACACUGAAAUUCAAAGUCAUGCUCAUAACUGUUAAUGAAAG… 1129 nt 0.3906
NM_001379310.1 NCBI
CAGUUAGUACACUGAAAUUCAAAGUCAUGCUCAUAACUGUUAAUGAAAG… 1102 nt 0.3884
NM_001379311.1 NCBI
CAGUUAGUACACUGAAAUUCAAAGUCAUGCUCAUAACUGUUAAUGAAAG… 1093 nt 0.3715
NM_001379312.1 NCBI
CAGUUAGUACACUGAAAUUCAAAGUCAUGCUCAUAACUGUUAAUGAAAG… 1054 nt 0.3890
NM_002113.3 NCBI
CAGUUAGUACACUGAAAUUCAAAGUCAUGCUCAUAACUGUUAAUGAAAG… 1297 nt 0.3832
Summary

This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome. [provided by RefSeq, Oct 2009]

Forensic Context

A study in humans identified the CFHR1 as a plasma protein exhibiting large abundance shifts between severe and nonsevere alcohol-associated hepatitis, classifying it as a severity discriminant within a signature useful for diagnostic assessment [Argemi et al. DOI:10.1016/J.Ajpath.2022.08.009].