Basic Information

Symbol
CHCHD10
RNA class
mRNA
Alias
Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 10 C22orf16 N27C7-4 MIX17A Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 10, Mitochondrial MIX17 Homolog A Chromosome 22 Open Reading Frame 16 Protein N27C7-4 FTDALS2 IMMD SMAJ
Location (GRCh38)
22:23765834-23767982
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_213720.3
Sequence length
700.0 nt
GC content
0.6700

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-295.90 kcal/mol
Thermodynamic ensemble
Free energy: -306.75 kcal/mol
Frequency: 0.0000
Diversity: 147.89
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((((((((((((((((......((((((((((.....((((((((.((((...)))).))).........(((.((.(((......)))..)).))).......))))).))))))))))((((....))))...))))))..((((((.((((.(.((..((((...((.((......((((.((.(.(((((((((.((....((((....))))..)).)))))....))))).)).))))......))))...)))).)).).)))).)))))).((((((.((((.((((...)))))))).(((((...(((((((((......(((....)))..(((((((....))))))).....))))))))).......(((((.......))))).....((((........)))).)))))((((....)))).((((...))))...))))))(((.(.((((((((...)))))))).).)))((((((.........(((((((.(((..(.((.....((((((.((((((((((.((...))))).))))))).)))))).......)).)..))))))))))..........))))))((((....))))...(((..(((((((...))))))).))).....................))))))..)))))................
Thermodynamic Ensemble Prediction
,{(,,((((((((((((.{....((((((((((.....((((((((.((((...)))).))).........(((.((.(((......)))..)).))).......))))).))))))))))((((....))))..,))))))..((((((.((((.(.((..{(((...{(,({......((((.((.{.(((((((((.((.,,.((((....)))}..)).)))))....))))}.)).)))).....,)}))}.,)))).)).).)))).)))))).((({{{.((((.((((,,,|}}}}}}}.{{,({...{{||((((((.({{.,,|}},})))}.(((((((....))))))).....},}})))))}}}....(((((.......)))))...,.((({........)))),}},,,{(({..,.}))}.{{{,...,)))}}.}}))}|(((.{.((((((((...)))))))).,.)))}{|||,.........(((((((.(((..(.((...{.((((((.((((((((((.((...)))))},)))))).)))))).......)).)..))))))))))..,.......}))),(((((....)))))..(((..(((((({...})))))).))}.....................))))))..}}}}|,,,....,,,,,....

Transcripts

ID Sequence Length GC content
NM_001301339.2 NCBI
CUUUUUUGCGCCGGCUGUGACAAGCGCUGCGGCAUUUGUCCCCGCGACA… 721 nt 0.6685
NM_213720.3 NCBI
CUUUUUUGCGCCGGCUGUGACAAGCGCUGCGGCAUUUGUCCCCGCGACA… 700 nt 0.6700
Summary

This gene encodes a mitochondrial protein that is enriched at cristae junctions in the intermembrane space. It may play a role in cristae morphology maintenance or oxidative phosphorylation. Mutations in this gene cause frontotemporal dementia and/or amyotrophic lateral sclerosis-2. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 7 and 19. [provided by RefSeq, Aug 2014]

Forensic Context

A study in Sprague-Dawley rats demonstrated that the gene CHCHD10 was among the top five differentially expressed genes upregulated in the spinal cord at 3 and 7 days post-tibial fracture compared to a 0-day control [Deng et al. DOI:10.1038/s41598-025-17561-6].