Basic Information

Symbol
CLTA
RNA class
mRNA
Alias
Clathrin Light Chain A Lca Clathrin, Light Polypeptide (Lca) Clathrin, Light Chain A
Location (GRCh38)
9:36190856-36304781
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001833.4
Sequence length
1078.0 nt
GC content
0.5464

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-389.60 kcal/mol
Thermodynamic ensemble
Free energy: -409.32 kcal/mol
Frequency: 0.0000
Diversity: 373.53
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...........((((.(.((((((((((.(((((((((.((((((..........((((.((((((((((...((((((((((((.((((.((.......)).))))..((((.(((.((.(((((((((((......)))..))))))))..)).)))))))))))))))))))))))))))))))))))))))))..)))).))).)))))))).)).).))))...((((((.((.....))))))))..((((..((((((...(((((((((..(..(.((((.((((((((((....((((((((...(((((((((..(((..(((....))).)))))))))))).))))))))..)))........)))))))((((..((((...(((((((((((...((.((((....))))...)).....)))))).)))))........))))..))))(((((...((..........)).)))))..)))).)..)..))))))))).((((((((((((((((((((.((.(......((((((((.(((((..(((((((((((((.(((..((..(((.((...(((............)))..((((..((((..(....)..))))))))..(((((........)))))....(((.((((((((.(..(((((((((..(((((..(((((.......)))))..)).))).))))).........))))..).)))))))))))..))))).))..))).)))((((.((((..((....)).))))..))))..............((((((.(((((((....(.(((((....))))).).....)))))))..)))))).))))))))))......))))))))))))).....(((((((.....))))..)))..((((((((((((..((.(.(((((.(((.....))).))))).).)).)))))))).)))).((((((....))))))..(((....)))..))).))))))).)))....)))))))))).))))))..))))........
Thermodynamic Ensemble Prediction
..{{{,.....((,((((((((....(({.((((((((((((....((((((((....)))).))))((((((,(((((.(.((({.(((.(({{{{{(((,...,.(((((((((((,((((((..((((.(((({.(((((((((((.{(,|{{(||((((.,|{{{||||||(({((((......))))))))..,}},},})),))))}}))))..},,)).)))))).)))))....}))))..))))..))))).}...))))))))))},...)}}))))))...)))}}))}.)))}}).)))))}(((((((((..{{,..((({,..,))})))))))))))).{((,(((({.(((,,,,,,.,(((((,,,,,|}}}|(({{{{,..{({{{{{{,{(({{((,.{({(({{,{{({.((((((..((.{{(((..((((...))))..)),((({....,))}..........,}),)).))))))},||{(({{,,{(({..((((({,..((.,,,,}},..,}|}..,}}}.,|||}...}}}}.}||,,,,|||}|||.||||,|||{(({{((((,(((...,,..,{,,,||,..,,,{,{((((..(....}..))))))))..{{(((........}))))....{{{,((((((((,(,.(((((((((..(((((..(((((.......)))))..))},)).)))))....,,,.,)))),.}.)))))})))))...,,..,,...}|}|}},{,||,||{||.,,,..,})|}}}}.,||||.....,..,..,,.((((({.(((((((....{.(((({....})))).).....)))))))..)))))).|||)},}}))))},..,}))))))),))}..))))))))}}))))))).,}}}),,.,|||||}}),))}}).)},{((((.(((,...,))).))))})))))))))))).))),...)))))))).}),,,.,.,|{||,,.|||,...,((((.....,)))}..,},))))||,....,,,,.............

Transcripts

ID Sequence Length GC content
NM_001076677.3 NCBI
CCGCUUUACCCGUCUCCCUCCUGGCGCUUGUCCUCCUCUCCCAGUCGGC… 1132 nt 0.5424
NM_001184760.2 NCBI
CCGCUUUACCCGUCUCCCUCCUGGCGCUUGUCCUCCUCUCCCAGUCGGC… 1114 nt 0.5422
NM_001184761.2 NCBI
CCGCUUUACCCGUCUCCCUCCUGGCGCUUGUCCUCCUCUCCCAGUCGGC… 1073 nt 0.5452
NM_001184762.2 NCBI
CCGCUUUACCCGUCUCCCUCCUGGCGCUUGUCCUCCUCUCCCAGUCGGC… 922 nt 0.5662
NM_001311203.2 NCBI
CCGCUUUACCCGUCUCCCUCCUGGCGCUUGUCCUCCUCUCCCAGUCGGC… 805 nt 0.4857
NM_001311204.2 NCBI
CCGCUUUACCCGUCUCCCUCCUGGCGCUUGUCCUCCUCUCCCAGUCGGC… 1012 nt 0.5553
NM_001311205.2 NCBI
CCGCUUUACCCGUCUCCCUCCUGGCGCUUGUCCUCCUCUCCCAGUCGGC… 958 nt 0.5605
NM_001311206.2 NCBI
CCGCUUUACCCGUCUCCCUCCUGGCGCUUGUCCUCCUCUCCCAGUCGGC… 1040 nt 0.5519
NM_001833.4 NCBI
CCGCUUUACCCGUCUCCCUCCUGGCGCUUGUCCUCCUCUCCCAGUCGGC… 1078 nt 0.5464
NM_007096.4 NCBI
CCGCUUUACCCGUCUCCCUCCUGGCGCUUGUCCUCCUCUCCCAGUCGGC… 1168 nt 0.5385
Summary

Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, May 2010]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly upregulated the CLTA in cortical oligodendrocytes, as part of a broader disruption of lysosomal function and cytoskeletal regulation pathways [Oladapo et al. DOI:10.3390/Ijms26020649].