Basic Information
Symbol
circSHPRH
RNA Class
circRNA
Alias
SNF2 Histone Linker PHD RING Helicase
BA545I5.2
KIAA2023
SNF2, Histone-Linker, PHD And RING Finger Domain-Containing Helicase
SNF2 Histone Linker PHD RING Helicase, E3 Ubiquitin Protein Ligase
RING-Type E3 Ubiquitin Transferase SHPRH
E3 Ubiquitin-Protein Ligase SHPRH
FLJ90837
2610103K11Rik
EC 2.3.2.27
EC 3.6.4.-
RAD5
Location (GRCh37)
6:146106726-146285233
UCSC Genome Browser
Location (GRCh38)
6:145785590-145964097
Host gene
SHPRH
Host category
mRNA
Forensic tag(s)
Other applications
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_chr6_0218000 | Intergenic-Intergenic | chr6:146274804-146275043 | chr6:145953668-145953907 | 240 nt | 0.2875 |
| hsa_SHPRH_0014400 | Exon-Exon | chr6:146275826-146275989 | chr6:145954690-145954853 | 164 nt | 0.3720 |
| hsa_chr6_0218100 | Intergenic-Intergenic | chr6:146275886-146276257 | chr6:145954750-145955121 | 372 nt | 0.3575 |
| hsa_SHPRH_0014600 | Intron-Intron | chr6:146281177-146281482 | chr6:145960041-145960346 | 306 nt | 0.4020 |
Showing 151 to 154 of 154 entries
Forensic Context
A review of literature indicates that the circSHPRH is a tumor suppressor in brain cancer, specifically glioblastoma, where it is downregulated and its encoded SHPRH-146aa peptide inhibits glioma growth [Di Agostino et al. DOI:10.3389/fcell.2020.00389]. A review of human studies indicates that the circSHPRH is downregulated in colorectal cancer tissues and is associated with metastasis and survival, while its overexpression inhibits proliferation and cell cycle progression [Lee et al. DOI:10.1016/j.biopha.2018.12.052].