Basic Information
Symbol
circSPINK5
RNA Class
circRNA
Alias
Serine Peptidase Inhibitor Kazal Type 5
LEKTI
VAKTI
LETKI
NETS
NS
Lympho-Epithelial Kazal-Type-Related Inhibitor
Lymphoepithelial Kazal-Type-Related Inhibitor
Serine Protease Inhibitor Kazal-Type 5
DKFZp686K19184
FLJ21544
FLJ97536
FLJ97596
FLJ99794
Serine Protease Inhibitor, Kazal Type 5
LEKTI Isoform
Location (GRCh37)
5:147391170-147499954
UCSC Genome Browser
Location (GRCh38)
5:148011607-148120391
Host gene
SPINK5
Host category
mRNA
Forensic tag(s)
Tissue/body fluid identification
Forensic psychiatry evaluation
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_chr5_0228200 | Intergenic-Intergenic | chr5:147468917-147473305 | chr5:148089354-148093742 | 250 nt | 0.3160 |
| hsa_chr5_0228300 | Intergenic-Intergenic | chr5:147468917-147499871 | chr5:148089354-148120308 | 250 nt | 0.3200 |
| hsa_SPINK5_0000100 | Intergenic-Intron | chr5:147391170-147432724 | chr5:148011607-148053161 | 250 nt | 0.3200 |
| hsa_SPINK5_0000200 | Intron-Intron | chr5:147429869-147431797 | chr5:148050306-148052234 | 1929 nt | 0.3494 |
| hsa_chr5_0227800 | Intergenic-Intergenic | chr5:147432397-147480160 | chr5:148052834-148100597 | 250 nt | 0.3440 |
| hsa_chr5_0227900 | Intergenic-Intergenic | chr5:147432397-147499871 | chr5:148052834-148120308 | 250 nt | 0.2760 |
| hsa_SPINK5_0000300 | Intron-Intron | chr5:147432530-147439866 | chr5:148052967-148060303 | 250 nt | 0.3400 |
| hsa_chr5_0228000 | Intergenic-Intergenic | chr5:147439017-147473305 | chr5:148059454-148093742 | 250 nt | 0.3320 |
| hsa_SPINK5_0000400 | Intergenic-Exon | chr5:147443426-147499954 | chr5:148063863-148120391 | 2720 nt | 0.4338 |
| hsa_SPINK5_0000500 | Exon-Exon | chr5:147449886-147466095 | chr5:148070323-148086532 | 329 nt | 0.3921 |
Showing 1 to 10 of 21 entries
Forensic Context
A study in humans demonstrated that circSPINK5 is significantly decreased in the peripheral blood of Alzheimer's disease patients and may serve to distinguish them from other dementia cases [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. A study in humans demonstrated that the circSPINK5 is expressed as both mRNA and circular RNA (circRNA) in vaginal secretions and was detected in all vaginal secretion samples using a multiplex assay [Liu et al. DOI:10.1016/J.Fsigen.2020.102312]. Its inclusion in biomarker detection did not impair specificity, though sporadic cross-reactivity in saliva was noted [Liu et al. DOI:10.1007/s00414-019-02027-y].