Basic Information
Symbol
circTGM4
RNA Class
circRNA
Alias
Transglutaminase 4
TGP
Protein-Glutamine Gamma-Glutamyltransferase 4
Prostate-Specific Transglutaminase
Transglutaminase 4 (Prostate)
Prostate Transglutaminase
Transglutaminase P
Fibrinoligase
EC 2.3.2.13
TGase P
TGase-4
TG(P)
Transglutaminase-4
HTGP
Location (GRCh37)
3:44919213-44955907
UCSC Genome Browser
Location (GRCh38)
3:44877721-44914415
Host gene
TGM4
Host category
mRNA
Forensic tag(s)
Tissue/body fluid identification
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TGM4_0000100 | Intron-Intron | chr3:44919213-44919546 | chr3:44877721-44878054 | 334 nt | 0.4192 |
| hsa_chr3_0627500 | Intergenic-Intergenic | chr3:44922463-44923789 | chr3:44880971-44882297 | 1327 nt | 0.4145 |
| hsa_TGM4_0000200 | Exon-Exon | chr3:44926817-44938308 | chr3:44885325-44896816 | 508 nt | 0.5413 |
| hsa_TGM4_0000300 | Exon-Exon | chr3:44926817-44943423 | chr3:44885325-44901931 | 420 nt | 0.5429 |
| hsa_TGM4_0000400 | Exon-Exon | chr3:44926817-44952898 | chr3:44885325-44911406 | 174 nt | 0.5287 |
| hsa_chr3_0627600 | Intergenic-Intergenic | chr3:44931467-44931912 | chr3:44889975-44890420 | 446 nt | 0.5000 |
| hsa_TGM4_0000500 | Exon-Exon | chr3:44932095-44943423 | chr3:44890603-44901931 | 671 nt | 0.5276 |
| hsa_TGM4_0000600 | Exon-Exon | chr3:44938201-44943423 | chr3:44896709-44901931 | 422 nt | 0.5521 |
| hsa_TGM4_0000700 | Exon-Exon | chr3:44938201-44945479 | chr3:44896709-44903987 | 221 nt | 0.5792 |
| hsa_TGM4_0000800 | Intron-Intron | chr3:44940101-44940486 | chr3:44898609-44898994 | 386 nt | 0.5648 |
Showing 1 to 10 of 16 entries
Forensic Context
A study in humans demonstrated that circTGM4 is specifically expressed in liver tissue at rates much higher than in other tissues [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. Circular transcripts of TGM4, identified as a semen-specific biomarker in human samples, were shown to have a high proportion of circular transcripts in semen but a low proportion in urine, and the inclusion of these circular RNAs in detection via LC-primers significantly increased the assay's sensitivity for TGM4 in urine samples, lowering the detection limit to 0.012 ng of input total RNA without impairing specificity [Liu et al. DOI:10.1007/s00414-019-02027-y].