Basic Information
Symbol
circTGM4
RNA Class
circRNA
Alias
Transglutaminase 4
TGP
Protein-Glutamine Gamma-Glutamyltransferase 4
Prostate-Specific Transglutaminase
Transglutaminase 4 (Prostate)
Prostate Transglutaminase
Transglutaminase P
Fibrinoligase
EC 2.3.2.13
TGase P
TGase-4
TG(P)
Transglutaminase-4
HTGP
Location (GRCh37)
3:44919213-44955907
UCSC Genome Browser
Location (GRCh38)
3:44877721-44914415
Host gene
TGM4
Host category
mRNA
Forensic tag(s)
Tissue/body fluid identification
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TGM4_0000900 | Intron-Exon-Intron | chr3:44944000-44953417 | chr3:44902508-44911925 | 2837 nt | 0.4519 |
| hsa_TGM4_0001000 | Intron-Exon-Intron | chr3:44949266-44952898 | chr3:44907774-44911406 | 137 nt | 0.4891 |
| hsa_TGM4_0001100 | Exon-Exon | chr3:44951582-44952898 | chr3:44910090-44911406 | 416 nt | 0.4784 |
| hsa_TGM4_0001200 | Exon-Exon | chr3:44955249-44955740 | chr3:44913757-44914248 | 492 nt | 0.5000 |
| hsa_chr3_0627700 | Intergenic-Intergenic | chr3:44955374-44955628 | chr3:44913882-44914136 | 255 nt | 0.5373 |
| hsa_chr3_0627800 | Intergenic-Intergenic | chr3:44955575-44955907 | chr3:44914083-44914415 | 333 nt | 0.5285 |
Showing 11 to 16 of 16 entries
Forensic Context
A study in humans demonstrated that circTGM4 is specifically expressed in liver tissue at rates much higher than in other tissues [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. Circular transcripts of TGM4, identified as a semen-specific biomarker in human samples, were shown to have a high proportion of circular transcripts in semen but a low proportion in urine, and the inclusion of these circular RNAs in detection via LC-primers significantly increased the assay's sensitivity for TGM4 in urine samples, lowering the detection limit to 0.012 ng of input total RNA without impairing specificity [Liu et al. DOI:10.1007/s00414-019-02027-y].