Basic Information
Symbol
circTPCN1
RNA Class
circRNA
Alias
Two Pore Segment Channel 1
TPC1
KIAA1169
Voltage-Dependent Calcium Channel Protein TPC1
Two Pore Calcium Channel Protein 1
Two Pore Channel Protein 1
FLJ20612
Two-Pore Channel 1, Homolog
Location (GRCh37)
12:113663049-113736389
UCSC Genome Browser
Location (GRCh38)
12:113225244-113298584
Host gene
TPCN1
Host category
mRNA
Forensic tag(s)
Mechanical injury analysis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TPCN1_0005200 | Exon-Exon | chr12:113710463-113722442 | chr12:113272658-113284637 | 651 nt | 0.5115 |
| hsa_TPCN1_0005500 | Exon-Exon | chr12:113711037-113711473 | chr12:113273232-113273668 | 159 nt | 0.5157 |
| hsa_TPCN1_0005600 | Exon-Exon | chr12:113711037-113714840 | chr12:113273232-113277035 | 276 nt | 0.5181 |
| hsa_TPCN1_0005700 | Exon-Exon | chr12:113711037-113729482 | chr12:113273232-113291677 | 1245 nt | 0.5301 |
| hsa_TPCN1_0006000 | Exon-Exon | chr12:113711374-113718000 | chr12:113273569-113280195 | 500 nt | 0.5100 |
| hsa_TPCN1_0006100 | Exon-Exon | chr12:113714724-113728803 | chr12:113276919-113290998 | 1017 nt | 0.5320 |
| hsa_TPCN1_0006600 | Exon-Exon | chr12:113715994-113728048 | chr12:113278189-113290243 | 728 nt | 0.5316 |
| hsa_TPCN1_0006800 | Exon-Exon | chr12:113716577-113736389 | chr12:113278772-113298584 | 250 nt | 0.3560 |
| hsa_TPCN1_0007100 | Exon-Exon | chr12:113725968-113726039 | chr12:113288163-113288234 | 72 nt | 0.5833 |
| hsa_TPCN1_0007200 | Exon-Exon | chr12:113725968-113726299 | chr12:113288163-113288494 | 332 nt | 0.6024 |
Showing 21 to 30 of 90 entries
Forensic Context
A study in human traumatic brain injury (TBI) patients identified the circTPCN1 as a top up-regulated circular RNA (fold change 19.03) in brain injury tissues compared to adjacent contusion tissues, with its differential expression validated by qRT-PCR [Li et al. DOI:10.3389/fneur.2022.1086553]. The broader literature indicates that circular RNAs exhibit tissue-specific expression and can function as miRNA sponges, transcriptional regulators, and biomarkers for various conditions, including neurological disorders [Sema Misir et al. DOI:10.1038/s41418-022-00948-7].