Basic Information
Symbol
circTPCN1
RNA Class
circRNA
Alias
Two Pore Segment Channel 1
TPC1
KIAA1169
Voltage-Dependent Calcium Channel Protein TPC1
Two Pore Calcium Channel Protein 1
Two Pore Channel Protein 1
FLJ20612
Two-Pore Channel 1, Homolog
Location (GRCh37)
12:113663049-113736389
UCSC Genome Browser
Location (GRCh38)
12:113225244-113298584
Host gene
TPCN1
Host category
mRNA
Forensic tag(s)
Mechanical injury analysis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TPCN1_0005900 | Exon-Exon | chr12:113711037-113718000 | chr12:113273232-113280195 | 168 nt | 0.4762 |
| hsa_TPCN1_0006200 | Exon-Exon | chr12:113714724-113716640 | chr12:113276919-113278835 | 306 nt | 0.5425 |
| hsa_TPCN1_0006300 | Exon-Exon | chr12:113714724-113718000 | chr12:113276919-113280195 | 49 nt | 0.4082 |
| hsa_TPCN1_0006400 | Exon-Exon | chr12:113715045-113716042 | chr12:113277240-113278237 | 174 nt | 0.5287 |
| hsa_TPCN1_0006500 | Exon-Exon | chr12:113715045-113716640 | chr12:113277240-113278835 | 70 nt | 0.5286 |
| hsa_chr12_0100300 | Intergenic-Intergenic | chr12:113716004-113722560 | chr12:113278199-113284755 | 141 nt | 0.4894 |
| hsa_TPCN1_0006700 | Intron-Exon-Intron | chr12:113716043-113716941 | chr12:113278238-113279136 | 899 nt | 0.5083 |
| hsa_TPCN1_0006900 | Intron-Intron | chr12:113716641-113717955 | chr12:113278836-113280150 | 1315 nt | 0.4456 |
| hsa_chr12_0100400 | Intergenic-Intergenic | chr12:113717454-113720294 | chr12:113279649-113282489 | 2841 nt | 0.4579 |
| hsa_chr12_0100500 | Intergenic-Intergenic | chr12:113721314-113721569 | chr12:113283509-113283764 | 256 nt | 0.4688 |
Showing 71 to 80 of 90 entries
Forensic Context
A study in human traumatic brain injury (TBI) patients identified the circTPCN1 as a top up-regulated circular RNA (fold change 19.03) in brain injury tissues compared to adjacent contusion tissues, with its differential expression validated by qRT-PCR [Li et al. DOI:10.3389/fneur.2022.1086553]. The broader literature indicates that circular RNAs exhibit tissue-specific expression and can function as miRNA sponges, transcriptional regulators, and biomarkers for various conditions, including neurological disorders [Sema Misir et al. DOI:10.1038/s41418-022-00948-7].