Basic Information
Symbol
circTTC3
RNA Class
circRNA
Alias
Tetratricopeptide Repeat Domain 3
RNF105
DCRR1
TPRDIII
TPRD
RING-Type E3 Ubiquitin Transferase TTC3
Tetratricopeptide Repeat Protein 3
E3 Ubiquitin-Protein Ligase TTC3
RING Finger Protein 105
TPR Repeat Protein 3
TPR Repeat Protein D
TPRDII
TPRDI
Protein DCRR1
EC 2.3.2.27
Location (GRCh37)
21:38445709-38575408
UCSC Genome Browser
Location (GRCh38)
21:37073409-37203107
Host gene
TTC3
Host category
mRNA
Forensic tag(s)
Forensic psychiatry evaluation
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TTC3_0027000 | Exon-Exon | chr21:38559350-38570326 | chr21:37187049-37198025 | 1024 nt | 0.4775 |
| hsa_TTC3_0027100 | Exon-Exon | chr21:38559350-38572625 | chr21:37187049-37200324 | 1117 nt | 0.4772 |
| hsa_TTC3_0027300 | Intron-Intron | chr21:38559447-38560795 | chr21:37187146-37188494 | 1349 nt | 0.3692 |
| hsa_TTC3_0027400 | Exon-Exon | chr21:38560796-38564514 | chr21:37188495-37192213 | 294 nt | 0.4048 |
| hsa_TTC3_0027500 | Exon-Exon | chr21:38563635-38568337 | chr21:37191334-37196036 | 91 nt | 0.3626 |
| hsa_TTC3_0027600 | Intron-Intron | chr21:38567291-38567679 | chr21:37194990-37195378 | 389 nt | 0.5501 |
| hsa_chr21_0075400 | Intergenic-Intergenic | chr21:38568620-38569611 | chr21:37196319-37197310 | 992 nt | 0.4506 |
| hsa_chr21_0075500 | Intergenic-Intergenic | chr21:38574435-38574590 | chr21:37202134-37202289 | 156 nt | 0.2692 |
| hsa_chr21_0075600 | Intergenic-Intergenic | chr21:38574798-38575017 | chr21:37202497-37202716 | 220 nt | 0.3545 |
Showing 291 to 299 of 299 entries
Forensic Context
A study in humans demonstrated that the circTTC3 shows a significant decrease in the peripheral blood of Alzheimer's disease patients, suggesting its potential to distinguish this condition from other dementias [Misir et al. DOI:10.1038/s41418-022-00948-7]. In mice and rats, circTTC3 was markedly upregulated in ischemic myocardium post-myocardial infarction and counteracted hypoxia-induced ATP depletion and apoptotic death in cardiomyocytes via the miR-15b/Arl2 axis [Tian et al. DOI:10.3390/molecules26041155]. It also alleviated hypoxic injury in HaCaT cells via miR-449a/NF-κB and PI3K/AKT pathways [Huang et al. DOI:10.3390/cells11091381].