Predicted to enable SH3 domain binding activity and profilin binding activity. Involved in negative regulation of epithelial cell migration; negative regulation of ruffle assembly; and positive regulation of stress fiber assembly. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Forensic Context
A single-nucleus transcriptomics study in human postmortem brain tissue identified the EVL as a protein-coding gene downregulated in MSN.3-type medium spiny neurons in the nucleus accumbens of individuals with alcohol use disorder compared to controls [Van Den Oord et al. DOI:10.1111/Adb.13250].