Basic Information

Symbol
ATP6V1F
RNA class
mRNA
Alias
ATPase H+ Transporting V1 Subunit F ATP6S14 VATF V-ATPase Subunit F Vma7 ATPase, H+ Transporting, Lysosomal 14kDa, V1 Subunit F V-Type Proton ATPase Subunit F Vacuolar Proton Pump Subunit F V-ATPase 14 KDa Subunit H(+)-Transporting Two-Sector ATPase, 14kD Subunit Adenosinetriphosphatase 14k Chain Vacuolar ATP Synthase Subunit F Vacuolar Proton Pump F Subunit ATPase, Vacuolar, 14 KD V-ATPase F Subunit
Location (GRCh38)
7:128862856-128865847
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004231.4
Sequence length
678.0 nt
GC content
0.5546

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-233.20 kcal/mol
Thermodynamic ensemble
Free energy: -243.45 kcal/mol
Frequency: 0.0000
Diversity: 105.72
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((((.((((((...(((((((......))))...))).)))))).)))))...(((((((((((((..((((((((((((.((((((.((..........)).)))))).((((((((((((((((((((((...)))....................((((((((((..((......))(((.....)))............((((...........))))((((..(((((...............))))).))))...((((((((..(((....((((....((.((((((((.........((..((((((((.....)))).))))))..................((((.(((..((((((((((......((((.......)))).....))))))).)))))).))))...(((((.(((((((.....(((((((.(((((((....(((((.......)))))............((((....((........))...))))...............)))))))..).)))))).....)))..)))))))))))))))))...))..))))..)))..)))))))).)))))))))).)))))))))))))))...))))))))))).)))))..................))))))))))))).
Thermodynamic Ensemble Prediction
(((((.((((((...(((((((......))))...))).)))))).)))))...(((((((((((((..((((((((((((.((((((.((..,.......)).)))))).(((((((((((((((((((,,.....,|....................((((((((((..((,.....}},,,.,,{,|||.{{,,...,,}|((((...........))))((((,.,||||..,,},,,,......,,,||.,,,,...((((((((..(((.,..((((..,.{{.((((((((.........{,,.((((((((.....))))},)))}}........|.........((((.(((..((((((((((......((((.......)))).....))))))).)))))).))))...(((((.(((((((.....(({{{{({(((((,,....|||||}}....,||||}.,,.........((((....((........)}...))))...............))))))).}),)))))).....)))..))))))))}))))))))...})..))))..)))..)))))))).)))))))))).))))))))))))))}...)))))))))))}}))))..................))))))))))))).

Transcripts

ID Sequence Length GC content
NM_001198909.2 NCBI
GUUUCAGUGGCUUCUGGUGCUCUAGGGUGAGCUCUGCCCGGCUGCAGGG… 762 nt 0.5486
NM_004231.4 NCBI
GUUUCAGUGGCUUCUGGUGCUCUAGGGUGAGCUCUGCCCGGCUGCAGGG… 678 nt 0.5546
Summary

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is the V1 domain F subunit protein. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that the ATP6V1F gene, encoding a V-ATPase subunit, was up-regulated in serotonergic neurons of the ventral tegmental area during the addicting phase of nicotine self-administration [Fan et al. DOI:10.1016/J.Jgg.2024.08.009].