Basic Information

Symbol
BAD
RNA class
mRNA
Alias
BCL2 Associated Agonist Of Cell Death BCL2L8 BBC2 Bcl-XL/Bcl-2-Associated Death Promoter Bcl2-Associated Agonist Of Cell Death Bcl2 Antagonist Of Cell Death Bcl-2-Binding Component 6 Bcl-2-Like Protein 8 Bcl2-L-8 BCL2-Antagonist Of Cell Death Protein BCL-X/BCL-2 Binding Protein BCL2-Binding Component 6 BCL2-Binding Protein BBC6
Location (GRCh38)
11:64269828-64291946
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_032989.3
Sequence length
929.0 nt
GC content
0.6577

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-419.20 kcal/mol
Thermodynamic ensemble
Free energy: -433.13 kcal/mol
Frequency: 0.0000
Diversity: 258.58
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((..((((..(((((((((((((.(((((.((((((((.....(((((...((.(((((((.(((((.........))....))).)))))))..))..))))))))))))).)))))....(((((((((......((((..(((..........))).))))...(((((((((((((((....))).))).))))))..)))...((((.((..(((...)))..))))))(((.(((((((...(((((((((...((.(((...(((((.((((((((((((......(((.((((((((((((...(((((....))))).))))(((((..((((((..........)))).))..))))).....((((((((((.(..(......)..)))))))))))..((((((...))))))))))))))))).....((((.(((..(((..(((....))).....)))...))).).)))..))))))).))))).)))))...))).))((((.(((((..((...))))))))))))))).)))))))))))).))).........))))))))).(((((...)))))..)))))))...(((((((((.......((((..((....)).....))))....((.((.(((((...))))).)).)).((((((((....(((((((((.(.((.(((((......))))).).))))))))))).))))))))))))))))).((((((.....))))))....)))))))))).(((((..((((((((((((((((.(((((.(((........)))))))).........(((((.(.(((........))).).)))))))))))))........................)))))))).))))).)))...
Thermodynamic Ensemble Prediction
.(((..((((..(((((((((((({.(((((.((((((((.((..{{(((...({.({(((({.({({{....,,,,.||..,.})),}))))})..}}..||||||}||}}}}.}}|||,...{(({{{(((.|,...|||||,(((..........))).})))...||{((((((((((((....))).))},))))))..|||..{((((.((..(({...}))..))))))|||}|(((({(...{{{{|||{|...,|,||{...(({({.((((((({((({..,...(((,((((((((((((...(((((....))))).))))(((((.,(((({{..........)))}.))..)))))...,,((((((((({{(..{......}..))))))))))).,{((((,...}))))})))))))}))},..,.{{{|||||..,((..(((....))),,...}}},..)))|},}}),.))))))}.}}|}}.}}))),}.))).}}((((.(((((..{,...,}))))))))))))}},))))))))})).))).....,,,.})))))))).||||{,,,))))),,}))))))...((((((((({,.((((((((..((....})....,||||{...,,.|,,,,|})),,.)))))))))),((((((((....(((((((((.(.,(.(((((......))))).).}}))))))))).)))))))),)))))))).((((((.....))))))....)))))))))).(((((..((((((((((((((((.(((((.(((........)))))))).........(((((.{.(((........})),).)))))))))))))..,...............,.....)))))))).))))).)))...

Transcripts

ID Sequence Length GC content
NM_004322.3 NCBI
AACUAGGGCCCGGAGCCCGGGGUGCUGGAGGGAGGCGGCAGGCCCGGGU… 1240 nt 0.6589
NM_032989.3 NCBI
AGGCCCGGGUCAGGGGCCUCGAGAUCGGGCUUGGGCCCAGAGCAUGUUC… 929 nt 0.6577
Summary

The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL (B-cell lymphoma-extra large) and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Dec 2019]

Forensic Context

No relevant information is available at the moment.