Basic Information

Symbol
C1QA
RNA class
mRNA
Alias
Complement C1q A Chain Complement Component 1, Q Subcomponent, Alpha Polypeptide Complement Component 1, Q Subcomponent, A Chain Complement C1q Subcomponent Subunit A Complement C1q Chain A Complement Component C1q, A Chain C1QD1
Location (GRCh38)
1:22635057-22639681
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_015991.4
Sequence length
1091.0 nt
GC content
0.6095

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-467.50 kcal/mol
Thermodynamic ensemble
Free energy: -486.36 kcal/mol
Frequency: 0.0000
Diversity: 251.23
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((..(.((((((.((.((.(((((((......((((.(((((((((.((((.......)))).))((((((((((((((((((((....((((.((((((((((((.....))))))))))..)).))))))))))))))).)).....((.((((...)))).))..(((((((..((((((((..(((((((((.(((((((((((((((.((((((.(((((((((...(((.((((((....)))))).)))(((((((((......(((((........((((((((...(((((((((..(((..((((.....)).))..).)).)))))))))...)))))).))..((((.((...)))))).....))))).(((.(((((((((.((((......((....(((((.((.(((.....((((((....)))))).((((((...))))))....(((((..(((.....(((((.....((.....))....)))))...))))))))....((.((....)).)).)))..)))))))....))........)))).)).)))))))...)))......)))))))))...).))))))))...)))))).)))....)))))))...((((((.((((((((((...(((.....)))...)))))))))))))))).((.(((.......))).))((....))..)))))(((.(((...(((((......)))))...))))))..((((....))))..))).))))))....)))))))).))))))).)))))))((((((((((.((.................))))))))))))..)))))))))))......))))))).))..)).....)))))).).)))))((((((.........))))))((.(((((..(((((.(..((.(((((((..((((((((((((.(((((.....(.((((.......)))).).....)))))..))).)))))))))(((....))).)))))))))..).)).))).................))))).)).....
Thermodynamic Ensemble Prediction
.(((((,,{,(((((({,..{{,(((((((,,,...((((.(((((((((.((((.......)))).))((((((((((((((((((((....((((.((((((((((((.....))))))))))..)).))))))))))))))).)).....((.((((...)))).)).,(((((((..((((((((..(((((((((.,...,((((((((((.((((((.(((((((({...(((,((((((....)))))).)))(((((((((,,,...(((((........((((((((..,(((((((({..((...{(((,.....},))).,.}),))))))))).,.)))))).))..((((.((...)))))).....})))).{{{.(((((((((.((((......((....(((((.((.(((.....((((((....)))))).((((((...))))))....(((((..(((..,..(((((,.{{.({.....))..},)))))..,))))))))...{((,{....}}).},.)))..)})))))....,,.,......)))).)).)))))))...)))},....)))))))))...}.))))))))...)))))).))),...})))))),,,((((((.((((((((((...{(({....)))...)))))))))),))))).((,(((,,,,,..}|}.},{({{,,||..}||||(({|||,...{{{{{......})))).,..,,})),,||||},},))))..))).))))))....)))))))).))))))).)))))))((((((((({,((....,.,..........}})))))))))}..})))))))))}......})))))),|}..|}|,,{{|}},)),),)}))}((((((..,......)))))){|.{{|||}|||||{,|..((,({(((((..((((((((((((.(((((,......,||{.......}}}}.},..}.)))))..))).))))))))){({....})}.)))))))})..},)).)}}....,............}}))).)).....

Transcripts

ID Sequence Length GC content
NM_001347465.2 NCBI
ACUCCUGCUGGGCAGCCCACAGGGUCCCUGGGCGGAGGGCAGGAGCAUC… 1111 nt 0.6112
NM_001347466.2 NCBI
ACUCCCACACCAGCUGUUGCUGGGGCAGGACGCCCAAUGUCCCAGUCUU… 1414 nt 0.6096
NM_015991.4 NCBI
ACUCCUGCUGGGCAGCCCACAGGGUCCCUGGGCGGAGGGCAGGAGCAUC… 1091 nt 0.6095
Summary

This gene encodes the A-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum complement system. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]

Forensic Context

A study in mice demonstrated that the C1QA was increased in male monocyte-derived macrophages compared to females and was expressed higher in microglia than in monocyte-derived macrophages after spinal cord injury [Stewart et al. DOI:10.1186/s12974-021-02161-8]. In human sepsis patients, the C1QA was highly expressed in serum compared to healthy controls and was localized primarily within macrophage cell lines, identifying it as a potential diagnostic biomarker [Wang et al. DOI:10.2147/IDR.S380137].