Basic Information

Symbol
ACTC1
RNA class
mRNA
Alias
Actin Alpha Cardiac Muscle 1 CMD1R ACTC Actin, Alpha Cardiac Muscle 1 Actin, Alpha, Cardiac Muscle Alpha-Cardiac Actin EC 3.6.4.- CMH11 LVNC4 ASD5
Location (GRCh38)
15:34790107-34795912
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005159.5
Sequence length
1382.0 nt
GC content
0.5326

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-454.30 kcal/mol
Thermodynamic ensemble
Free energy: -482.74 kcal/mol
Frequency: 0.0000
Diversity: 418.19
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((((((..((..((((((...(.((((((.(((((((...(((.(((((.....(((((..((((......((((.((((((...(((...((.(((((.((.((.(((.((((((((....)))))))).).)).)).)).))))))).)))..)))))).))))))))(((((...))))))))))))))).))).)))))))..)))))).)..)).))))..))..))))..(((((...((((((((((((............((((.((.(((..((((((((((((.(((((.(((((((....((((((((((...((((((((((.(((......)))....))))))((((((..(((((........))))).....((((..............))))...))))))((((((.(((((..((.((..(((.(.((((.((((...(..(((.((.((((((((.((((((((((........((((((.(((.....))).))))))((((.(((((..(((((((.(((.....)))...)))))))...(((.((((........)))))))((......))....((((((((.(((((((.......)))))))))......))))))(((((.(((((((..((......))..)))).))).)..))))....))))).))))...(((((.(((((((((((.(((..((........))..))).)))).)))))))..))))).((((.....))))...))).....))))))))))))))).)))))..)....)))).)))).))))..))))..))))).)).))))(((((.....(((((....)))))....)))))..............((((....(((((..((..(((.((((.((...(((....))).......(((.....((((((((((((.....)))....((((.((.((.(((((((((...(((.(((((...(((.((((..(....).))))...)))((((..(((.((((((((.....))))...)))).)))))))((((.(((((((.......)))))))..)))).)))))..)))......))))))))))).)).)))))))))))))))).....)).)))))))..)).)))))..)))).)))).))).))))))).....)))))))..)).))).))))))))))))..))).))))))............)))).)))..........(((((((.((.((....)).))))))))).)))))..)))))...(((((((......)))))))..........)).)))........
Thermodynamic Ensemble Prediction
...{,.{(((,.((.,(({(((,..,.{{{{{|.{|||{||...{{{.{((((,,((((((({,.((({.,,,,.(({(,(({((({(,(((,,,((,(((((.{{.(({(((,(((({(({,,,,|}}|||},.|,||{||.}}.}}))))),))),)))))))}))))))}}.,})}},,..))))))))))))).}}}.))))))}..,|||||.|..}|.}}||,.|}..}||}.,({{{{.||,,||,{{{|||{....,||,,,,.((((..({({(..((((((((((((.(((((.(((((((.{,.((((((({((...((((,(,,,,..,,.....,|||{...|||,||((((,,.}||||,...}}}..,)))),.{{{((((..,.,{..{{{{{,}}||...}|||||{,(,.{.(((((((...)))))))..,,))..,.}}}},(((((,.,,,||||{,,{(((((((((...({{(({{((((,{.{(({.{{,|||{|||||,.((({(((,({{(((((((,{((,....})),.,)))))),...{((.((((........))))))}{{......}},,..((((((((.(((((((.......)))))))))......))))))(((({.(((((((..((......))..)))).))).}..))))...,|||,,.))))...{((((.(((((((((((.(((..((.,....,.))..))).))))},))))))..))))}.((((.....)))).)))))}}.)}))))))))}}}||||,||,,.......})))|.,,{({({,,,||}|({{.,{{|||,..,{{((({,{,.........}}..)))),..,|||||,{{,,{{{..,,..{{{.,,...,,.,..}},}}})}|,})}|}},.{{{,,..))},.,|,,}}}},.}}.||||||,.,|||}}}},,......{{,{.,|}}},|{|||||{,}}}|||}|,,||}...|}}}|}.}}||...,.}},....,},((((..(({{({,(((((.....))))),,}}},,)},))))||,|}||||{,|.......)))))))..||||{|,||,..,,,.,.)}})))|||,||{|{,,.}|}|({((.(({||,,,,,,,,.}}))}}}.,)},..)))))))},}.)))).,,)}))))))).,.}.)))))))..)).))).))))))))))))..))))..))))..........,.)))).)),,,},,..,,,,{{||||,||,|{....}}.}}|}||||,.,}}))),))}}}...(((((((......)))))))........,})).,..,,......

Transcripts

ID Sequence Length GC content
NM_001406482.1 NCBI
GUCCUGUCCUCUGGGUGCGGAGAAGGCCAGCUGCACAGGCAGCUAAGCG… 1416 nt 0.5304
NM_001406483.1 NCBI
AGAGCCCGCUGCCGCCGGAGCCGAGCCGACCCGCCCCGCCGACGGUGAG… 1730 nt 0.5497
NM_001406484.1 NCBI
GUCACAUGCCUGGCCAGACAGGCUGCCAAGCAGGAGAGCUUAGUCCUCA… 1463 nt 0.4846
NM_001406485.1 NCBI
GUCACAUGCCUGGCCAGACAGGCUGCCAAGCAGGAGAGCUUAGUCCUCA… 1410 nt 0.4809
NM_005159.5 NCBI
AGAGCCCGCUGCCGCCGGAGCCGAGCCGACCCGCCCCGCCGACGAACCC… 1382 nt 0.5326
Summary

Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). [provided by RefSeq, Jul 2008]

Forensic Context

A study in human and rat corpus cavernosum demonstrated that the ACTC1 is expressed exclusively in human cavernosal trabecular smooth muscle cells and is localized close to the cavernous sinus lumen [Yin et al. DOI:10.1016/j.celrep.2024.114760]. A study in rats demonstrated that heat exposure induces rapid molecular changes in cardiac tissue, with mRNA expression of the ACTC1 gradually decreasing in both the atrium and ventricle for up to 2-4 hours post-exposure before returning to control levels by 8 hours, indicating altered myocardial contraction [Nakagawa et al. DOI:10.1016/J.Legalmed.2011.12.001].