Basic Information

Symbol
CD14
RNA class
mRNA
Alias
CD14 Molecule Myeloid Cell-Specific Leucine-Rich Glycoprotein Monocyte Differentiation Antigen CD14 CD14 Antigen My23 Antigen
Location (GRCh38)
5:140631728-140633700
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_000591.4
Sequence length
1356.0 nt
GC content
0.6084

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-519.20 kcal/mol
Thermodynamic ensemble
Free energy: -541.05 kcal/mol
Frequency: 0.0000
Diversity: 505.24
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..(((.(((..(((((((((.((((((...))))))..(((........))).....))))))).))..(((.((.(((..((((((((((.((......((((((((((..(((((((.((((...((.((....)).))..((((((...(((.....)))..))))))........)))).))))).)).....))))).)).))).......))))))))))))))))))))(((((.((((((...((((.((.(((....(((.((((((.((.((((((((((((.(((......)))))).......(((.((((((((((((.(((((((..(((((...)))))....))))..)))..))))))).))))))))...((((((((((.....))))))))))......((((((.((((...)))).)))))).......(((((((.(((..((........))..)))..........(((..(((((((((((((((((((((.(((...(((.........)))..((((((((((((((...)).)))))))).))))((((((.(((((....(((((((....))))))).)))))((((..(((((...(((...(((....)))..)))((..((((.(((....))).))))..)))))))...)))).......((((((.((..............)).))))))))))))(((((..(((.(((.....))).)))..)))))..)))..))))))....((.((.(((((.(((.....(((......))).....)))))))).)).)))))))))).)))))))..)))..........((((.((....((.((((..((((................))))..)))).))..)).))))..((((((((.......(((.(((((.((..((((((((((..(((...((....)).))))))))).(((.......)))......)))).)).))))).))).)))))))).((((((....).)))))..)))))))....((.(((.(.(((.(((...))).))).))))...))....((((((......))))))..........)))))))))))))).))).))).((((((...(((((.....((((.(.(((..((((((.(((.((...)).))))))))).....))).).))))..))))).....))))))))).)).))))....)))))).(((((((((..((((....))))))))))))))))))................))))))....................
Thermodynamic Ensemble Prediction
..{{(.(((..(((((((((,((((((...)))))},,{{{.......,|},..}}.))))))).||{,{(,{((.{({..{||{||||||||{.,,.,,{((({((({({,({(((((.(((({,.((,((.,{,||,||{{(((((((,.{,{..,|||}}..}|||||.,,,,,|,|}}|,||}}}.||..,..}}}}},}}.))}.|,,...}}}}))}}}}}}})}}}}}},|||{,{{{({(,,,((({.{{.{{{.{{{(({{((((((.{{.{{{(((((({((,(((......|||}}|,,,,,..(((.((((((((((((.(((((((.,(((((...})))).,..))))..)))..))))))).)))))))}...((((((((((.....)))))))))).||,..{{((((,((((...))}),))})}},{,..,.{|||{{,.,||},|.,,,}}},,|||.,,,...,....,,|||,.,,,|||||.|||||{{|||||||{{..,||||,.{,.....,,,}|{((((((((((({...}).)))))))).))))||||||,}||||,,}.|}|,|||}}},)})))}}.,))||||||.,,,|||.}}}|}}..|||...,))}||},||{{||||,.{{{{{({({{.,,,||}|}(((.....))).....,{{({((((||||{|....,,...{{||{,{|||{{..|{,(((((..(((.(((.....))).)))..)))))})),)),)))))..}}}}|.||}||||..,.|}}}},,|,{.{{{{{....))))),)})||{||.,,}))))))))))}}}})},)),.,}},|,...((((.((,,,,,,.((((..((((................))))..)))).}),.)).))))..((((((((.......{({.(((((.({..((({((((((..({(,{.({....)),))))))))).{{|.....,.}}}.....,}})),)).))))}.))).)))))))).||||{,.,..).))))),,)|))),},,.,{{|{{(.,.(((,(((,..}}},))),|}))|.,||,...((((((......))))))..........}}}}}|}|||}}}|||}},}}},({((({,,,{{{{{,,|||{{||,|,{{|..((((((.{{{.{{,,.}),)))))))}),|||.}}|.,,,}|||.}}||}.....}}}}})))}.)).})))..,,)))))),{(({|((((,.||||}..{||||||,,,})))))),....,..,.....},..)))))}....................

Transcripts

ID Sequence Length GC content
NM_000591.4 NCBI
ACAAGUGUGAAGCCUGGAAGCCGGCGGGUGCCGCUGUGUAGGAAAGAAG… 1356 nt 0.6084
NM_001040021.3 NCBI
AAUUCUACCCCCCUUGGUGCCAACAGAUGAGGUUCACAAUCUCUUCCAC… 1544 nt 0.5855
NM_001174104.2 NCBI
AAUUCUACCCCCCUUGGUGCCAACAGAUGAGGUUCACAAUCUCUUCCAC… 1644 nt 0.5827
NM_001174105.2 NCBI
AAUUCUACCCCCCUUGGUGCCAACAGAUGAGGUUCACAAUCUCUUCCAC… 1523 nt 0.5883
Summary

The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide, and to viruses. This gene has been identified as a target candidate in the treatment of SARS-CoV-2-infected patients to potentially lessen or inhibit a severe inflammatory response. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2020]

Forensic Context

A study in mice demonstrated that brain injury following clodronate-induced monocyte depletion leads to the emergence of transcriptionally distinct CD115+/Ly6Chi monocyte subsets, including immunoregulatory monocytes enriched for Apoe and Chil3 and a unique neutrophil-like monocyte cluster defined by granule genes Elane, Prtn3, MPO, and Ctsg [Gudenschwager Basso et al. DOI:10.1186/s12974-024-03032-8].